In infectious disease surveillance, incidence data are frequently subject to reporting delays and retrospective corrections, making it hard to assess current trends in real time. A variety of probabilistic nowcasting methods have been suggested to correct for the resulting biases. Building upon a recent comparison of eight of these methods in an application to COVID-19 hospitalization data from Germany, the objective of this paper is twofold. Firstly, we investigate how nowcasts from different models can be improved using statistical post-processing methods as employed, e.g., in weather forecasting. Secondly, we assess the potential of weighted ensemble nowcasts, i.e., weighted combinations of different probabilistic nowcasts. These are a natural extension of unweighted nowcast ensembles, which have previously been found to outperform most individual models. Both in post-processing and ensemble building, specific challenges arise from the fact that data are constantly revised, hindering the use of standard approaches. We find that post-processing can improve the individual performance of almost all considered models both in terms of evaluation scores and forecast interval coverage. Improving upon the performance of unweighted ensemble nowcasts via weighting schemes, on the other hand, poses a substantial challenge. Across an array of approaches, we find modest improvement in scores for some and decreased performance for most, with overall more favorable results for simple methods. In terms of forecast interval coverage, however, our methods lead to rather consistent improvements over the unweighted ensembles.
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http://dx.doi.org/10.1371/journal.pcbi.1012836 | DOI Listing |
Ann Med
December 2025
Department of Assisted Reproductive Centre, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, China.
Background: Butyrate may inhibit SARS-CoV-2 replication and affect the development of COVID-19. However, there have been no systematic comprehensive analyses of the role of butyrate metabolism-related genes (BMRGs) in COVID-19.
Methods: We performed differential expression analysis of BMRGs in the brain, liver and pancreas of COVID-19 patients and controls in GSE157852 and GSE151803.
An Pediatr (Engl Ed)
March 2025
Servicio de Pediatría, Enfermedades Infecciosas y Tropicales, Hospital Universitario La Paz, Fundación IdiPaz, CIBERINFEC, Madrid, Spain; Sociedad Española de Infectología Pediátrica (SEIP), Madrid, Spain.
Floods constitute one of the most widely described natural phenomena worldwide, and their frequency is increasing due to the consequences of climate change. Floods pose risks to the affected populations, including an increase in communicable diseases mainly due to population displacement and overcrowding, deficiencies in hygiene and dietary measures and difficulties accessing health care. The most frequently reported infectious diseases in the context of these disasters are gastrointestinal and respiratory diseases and diseases resulting from wound infection.
View Article and Find Full Text PDFAtherosclerosis
March 2025
University Medical Center Mainz, Department of Cardiology at the Johannes Gutenberg University, Germany; German Cardiovascular Research Center (DZHK), Partner Site Rhine Main, Mainz, Germany.
Soil and water pollution represent significant threats to global health, ecosystems, and biodiversity. Healthy soils underpin terrestrial ecosystems, supporting food production, biodiversity, water retention, and carbon sequestration. However, soil degradation jeopardizes the health of 3.
View Article and Find Full Text PDFJ Microbiol Immunol Infect
March 2025
Chang Gung Microbiota Therapy Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan. Electronic address:
Background: Clostridium innocuum is a vancomycin-resistant pathobiome associated with poor clinical outcomes in inflammatory bowel disease (IBD). In ulcerative colitis (UC), it correlates with reduced remission rates, while in Crohn's disease (CD), it is linked to creeping fat formation and intestinal strictures. Notably, some patients experience refractory or recurrent C.
View Article and Find Full Text PDFJ Microbiol Immunol Infect
March 2025
Division of Pediatric Infectious Diseases, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Chang Gung University School of Medicine, Taoyuan, Taiwan. Electronic address:
Background: Strict mask wearing and handwashing were implemented in hospital settings during COVID-19 pandemic in Taiwan. To explore if nasal methicillin-resistant Staphylococcus aureus (MRSA) carriage rate among inpatients in the hospital changed before and after COVID-19, we conducted this study.
Methods: Patients who were admitted to a regional hospital in central Taiwan during one week in 2012 and 2023, respectively, were enrolled.
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