Home Owners' Loan Corporation (HOLC) maps illustrated patterns of segregation in United States cites in the 1930s. As the causes and drivers of demographic and land-use segregation vary over years, these maps provide an important spatial lens in determining how patterns of segregation spatially and temporally developed during the past century. Using a high-resolution land-use time series (1937-2018) of Denver, Colorado, USA, in conjunction with 80 years of U.S. Census data, we found divergent land-use and demographics patterns across HOLC categories were both pre-existent to the establishment of HOLC mapping and continued to develop over time. Over this period, areas deemed "declining" or "hazardous" had more diverse land use compared to "desirable" areas. "Desirable" areas were dominated by one land-use type (single-family residential), while single-family residential diminished in prominence in the "declining/hazardous" areas. This divergence became more established decades after HOLC mapping, with impact to racial metrics and low-income households. We found changes in these demographic patterns also occurred between 2000 and 2019, highlighting how processes like gentrification can develop from both rapid demographic and land-use changes. This study demonstrates how the legacy of urban segregation develops over decades and can simultaneously persist in some neighborhoods while providing openings for fast-paced gentrification in others.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875366 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0317988 | PLOS |
Magn Reson Med
March 2025
Center for Magnetic Resonance Research, Radiology, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
Purpose: To propose a two-step, nonlocal principal component analysis (PCA) method and demonstrate its utility for denoising complex diffusion MR images with a few diffusion directions.
Methods: A two-step denoising pipeline was implemented to ensure accurate patch selection even with high noise levels and was coupled with data preprocessing for g-factor normalization and phase stabilization before data denoising with a nonlocal PCA algorithm. At the heart of our proposed pipeline was the use of a data-driven optimal shrinkage algorithm to manipulate the singular values in a way that would optimally estimate the noise-free signal.
J Cell Sci
March 2025
Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Mitochondria perform diverse functions, such as producing ATP through oxidative phosphorylation, synthesizing macromolecule precursors, maintaining redox balance, and many others. Given this diversity of functions, we and others have hypothesized that cells maintain specialized subpopulations of mitochondria. To begin addressing this hypothesis, we developed a new dual-purification system to isolate subpopulations of mitochondria for chemical and biochemical analyses.
View Article and Find Full Text PDFNeurol Neurochir Pol
March 2025
Department of Neurosurgery, Medical University of Gdansk, Gdansk, Poland.
Introduction: This study aimed to identify predictive factors for long-term incomplete nidus obliteration following stereotactic radiosurgery (SRS) for brain arteriovenous malformations (AVMs).
Material And Methods: A systematic search across the PubMed, Web of Science, and Scopus databases identified observational studies reporting such factors. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed.
J Chem Theory Comput
March 2025
Department of Chemistry, Iowa State University, Ames, Iowa 50011, United States.
Protein evolution has shaped enzymes that maintain stability and function across diverse thermal environments. While sequence variation, thermal stability and conformational dynamics are known to influence an enzyme's thermal adaptation, how these factors collectively govern stability and function across diverse temperatures remains unresolved. Cytosolic malate dehydrogenase (cMDH), a citric acid cycle enzyme, is an ideal model for studying these mechanisms due to its temperature-sensitive flexibility and broad presence in species from diverse thermal environments.
View Article and Find Full Text PDFJ Ment Health
March 2025
School of Social Work, Arizona State University, Phoenix, AZ, USA.
Background: Media portrayals inform understandings of mental illness; yet little research has investigated representations of characters with psychosis in fictional television programming.
Aims: This study examined the valence and trends regarding representations of people with psychosis in popular fictional television programing in the United States, one of the most influential markets in the world.
Methods: A content analysis was conducted of the 50 most-watched American primetime fictional television shows from 2011 to 2021.
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