This article reports a case of rare pulmonary metastases arising from an ovarian granulosa cell tumor using 18F-NOTA-FAPI-04 PET/CT. We discussed a patient who was diagnosed with ovarian granulosa cell tumor (stage IA) after surgery 15 years ago and developed pulmonary metastases. The metastatic lesions with solid and (or) cystic components displayed variable (none to mild) fluorodeoxyglucose (FDG) avidity and significantly higher uptake of FAPI. This case highlighted the utility of 18F-NOTA-FAPI-04 PET/CT, suggesting that it may serve as a promising novel tool for the diagnosis and staging of ovarian granulosa cell tumors.
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http://dx.doi.org/10.1097/RLU.0000000000005801 | DOI Listing |
Poult Sci
March 2025
Department of Animal Science, National Chung Hsing University, Taichung 40227, Taiwan; The iEGG and Animal Biotechnology Center and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung 40227, Taiwan; i-Center for Advanced Science and Technology (iCAST), National Chung Hsing University, Taichung 40227, Taiwan. Electronic address:
In mammals, tissues other than liver and intestine are known to possess functional MTTP (microsomal triglyceride transfer protein) and apoB (apolipoprotein B) capable of VLDL (very low-density lipoprotein) assembly. Birds are oviparous and possess unique capabilities in lipid biology to accommodate yolk formation through massive deposition of hepatically assembled yolk-targeted VLDLy into ovarian follicles. Following identifications of MTTP and ApoB expression within chicken ovarian stroma, granulosa, theca, and epithelial cells of various classes of follicles, we sought to define the functionality of ovarian MTTP and ApoB in VLDL assembly.
View Article and Find Full Text PDFBr Poult Sci
March 2025
State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Agricultural Bioinformatics, Ministry of Education, Key Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, College of Animal and Technology, Sichuan Agricultural University, Chengdu, China.
1. A study was conducted to investigate the effect of spermidine on cuproptosis in granulosa cells of goose ovarian follicles. Granulosa cells from F2-F5 grade follicles of Sichuan white geese were isolated and cultured.
View Article and Find Full Text PDFCells
February 2025
NUS Bia-Echo Asia Centre of Reproductive Longevity and Equality, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456, Singapore.
The ovary is a dynamic organ where mechanical forces profoundly regulate follicular development, oocyte maturation, and overall reproductive function. These forces, originating from the extracellular matrix (ECM), granulosa and theca cells, and ovarian stroma, influence cellular behavior through mechanotransduction, translating mechanical stimuli into biochemical responses. This review explores the intricate interplay between mechanical cues and ovarian biology, focusing on key mechanosensitive pathways such as Hippo signaling, the PI3K/AKT pathway, and cytoskeletal remodeling, which govern follicular dormancy, activation, and growth.
View Article and Find Full Text PDFJ Ovarian Res
March 2025
Department of Cardiology, Center for Genetic Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, China.
Background: Cyclophosphamide (CTX) often induces oocyte and granulosa cell injury, leading to fertility loss in young female cancer survivors. Deciphering the mechanisms underlying follicular cell injury could offer novel insights into fertility preservation. Granulosa cells represent the most abundant cell type within the follicles and can be generally categorized as cumulus granulosa cells (CGCs) and mural granulosa cells (MGCs).
View Article and Find Full Text PDFYi Chuan
March 2025
Key Laboratory of Genetics Breeding and Reproduction of Grass Feeding Livestock, Ministry of Agriculture and Rural Affairs, Key Laboratory of Animal Biotechnology of Xinjiang, Institute of Biotechnology, Xinjiang Academy of Animal Sciences, Urumqi 830011, China.
Follicle development is a crucial step in mammalian reproductive processes, the specific role of Mfn2 in regulating mitochondrial function and endoplasmic reticulum stress in this process is still unclear, this study aimed to investigate the role of Mfn2 in the follicular development of adult sheep. Large, medium, and small follicles were collected, and granulosa cells (GCs) were isolated from large follicles. The expression levels of Mfn2 in different follicles were detected using qRT-PCR and Western blot, and the localization of Mfn2 in follicles was determined through immunofluorescence.
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