A new method for mapping torsion provides insights into the ways that the genome responds to the torsion generated by RNA polymerase II.
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http://dx.doi.org/10.7554/eLife.106351 | DOI Listing |
Elife
March 2025
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, United States.
A new method for mapping torsion provides insights into the ways that the genome responds to the torsion generated by RNA polymerase II.
View Article and Find Full Text PDFHSS J
July 2020
Department of Orthopaedic Surgery, Hospital for Special Surgery, 535 E. 70th St., New York, NY 10021 USA.
Background: Lumbar interbody fusion is among the most common types of spinal surgery performed. Over time, the term has evolved to encompass a number of different approaches to the intervertebral space, as well as differing implant materials. Questions remain over which approaches and materials are best for achieving fusion and restoring disc height.
View Article and Find Full Text PDFMed Microbiol Immunol
June 2020
Astbury Centre for Structural Molecular Biology, School of Biomedical Science, University of Leeds, Leeds, LS2 9JT, England, UK.
There are many Ph.D. programs from various funding agencies that provide excellent starts to a scientific career.
View Article and Find Full Text PDFEur J Immunol
December 2013
Department of Medicine, Medical Research Service, Durham Veterans Affairs Medical Center, Duke University Medical Center, Durham, NC, USA.
Histones are highly cationic proteins that are essential components of the cell nucleus, interacting with DNA to form the nucleosome and regulating transcription. Histones, however, can transit from the cell nucleus during cell death and, once in an extracellular location, can serve as danger signals and activate immune cells. An article in this issue of the European Journal of Immunology [Eur.
View Article and Find Full Text PDFAutoimmunity
June 2011
Research Professor of Medicine, Division of Rheumatology, New York University Hospital for Joint Diseases, USA.
In this introduction the timeliness and interest of dedicating an issue of Autoimmunity to mostly "discrete" models is motivated by highlighting number of circumstances, observations encounters, that all have favored the rise of a family of agent based simulations of the Immune System. Franco Celada was among the first experimentalists to accept the challenge of interdisciplinarity and create a computational Immune System. He thinks that discrete models are especially useful in handling hypotheses: initiating them, representing their consequences, and revealing their plusses and minuses.
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