Plants in the genus Pistacia represent valuable natural resources for neuroprotective research based on ethnomedicinal knowledge. While other Pistacia species have been extensively studied, () has received limited attention. This study aimed to characterise the phenolic compounds in extract using HPLC-DAD-MS/MS and evaluate its neuroprotective potential by assessing its ability to inhibit important central nervous system (CNS) enzymes-acetylcholinesterase (AChE) and monoamine oxidases (MAO-A and MAO-B). displayed a rich profile of phenolic acids and unique glucuronidated flavonoids, contributing to its potent antioxidant activity (IC50 23.37 ± 0.63 µg/mL). The extract exhibited a stronger inhibitory effect on MAO-B than MAO-A and inhibited AChE (IC50 0.22 ± 0.01 mg/mL). These findings suggest that has significant neuroprotective potential, warranting further investigation as a source of functional food and nutraceutical ingredients for managing neurodegenerative diseases.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/14786419.2025.2472272 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Explore peptides extracted from gliadin hydrolysates suppressing BACE1 activity and restraining Aβ protein deposition.
Int J Biol Macromol
March 2025
Institute of Translational Medicine and New Drug Development, China Medical University, Taichung 404333, Taiwan; Department of Biomedical Sciences and Engineering, Tzu Chi University, Hualien 970374, Taiwan. Electronic address:
Alzheimer's Disease (AD) constitutes approximately 70 % of dementia cases and is the most prevalent form of dementia. Current therapeutic options, including acetylcholinesterase inhibitors and N-methyl d-aspartate (NMDA) receptor antagonists, provide symptomatic relief but do not cure the disease and often come with side effects. The primary pathological features of AD are amyloid plaques and neurofibrillary tangles, with amyloid plaques formed by the abnormal accumulation of Amyloid-β (Aβ).
View Article and Find Full Text PDFErianin isolated from Dendrobium huoshanense alleviated neuroinflammation in MPTP-induced Parkinson's disease model via NF-κB/NLRP3 pathway.
J Ethnopharmacol
March 2025
School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, China; Key Laboratory of Chinese Medicinal Resource and Chinese Herbal Compound of the Ministry of Education, Hubei University of Chinese Medicine, Wuhan, 430065, China; Center of Traditional Chinese Medicine Modernization for Liver Diseases, Hubei University of Chinese Medicine, Wuhan, 430065, China; Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, 430065, China. Electronic address:
Ethnopharmacological Relevance: Parkinson's disease (PD) is one of the most common neurodegenerative disorders, yet effective therapeutic options remain limited. Dendrobium huoshanense (DH), a medicinal and edible herb mainly distributed in Ta-pieh Mountains of Central China, has been used to treat disorders of consciousness and chronic nervous diseases in the local hospital for thousands of years. Erianin, a bioactive bibenzyl compound isolated from DH, has emerged as a potential neuroprotective agent due to its anti-inflammatory and antioxidant properties.
View Article and Find Full Text PDFUnlocking the therapeutic potential of gut microbiota for preventing and treating aging-related neurological disorders.
Neuroscience
March 2025
Manipal Centre for Biotherapeutics Research, Manipal Academy of Higher Education, Karnataka, Manipal 576 104, India. Electronic address:
Billions of microorganisms inhabit the human gut and maintain overall health. Recent research has revealed the intricate interaction between the brain and gut microbiota through the microbiota-gut-brain axis (MGBA) and its effect on neurodegenerative disorders (NDDs). Alterations in the gut microbiota, known as gut dysbiosis, are linked to the development and progression of several NDDs.
View Article and Find Full Text PDFNoninvasive ocular delivery of adalimumab-loaded nanostructured lipid carriers for targeted retinitis pigmentosa therapy.
Biomed Pharmacother
March 2025
Group of Pathophysiology and Therapies for Vision Disorders, Príncipe Felipe Research Center (CIPF), Eduardo Primo Yúfera 3, Valencia 46012, Spain; Joint Research Unit on Rare Diseases CIPF-Health Research Institute Hospital La Fe (IIS-La Fe), Valencia 46026, Spain; Biomedical Research Networking Center in Rare Diseases (CIBER-ER), Institute of Health Carlos III, Monforte de Lemos, 3-5. Pabellón 11, Madrid 28029, Spain; Catholic University of Valencia (UCV), Faculty of Health Sciences, Quevedo, 2, Valencia 46001, Spain. Electronic address:
Retinitis pigmentosa is a genetically heterogeneous retinal degeneration process. There is hardly any treatment available. It is associated with extensive chronic inflammation and the release of proinflammatory cytokines such as TNFα.
View Article and Find Full Text PDFQuercetin-derived carbon dots promote proliferation and migration of Schwann cells and enhance neurite outgrowth.
Colloids Surf B Biointerfaces
March 2025
Department of Medical and Translational Biology, Umeå University, Umeå SE-901 87, Sweden. Electronic address:
Quercetin, a flavonoid known for its antioxidant properties, has recently garnered attention as a potential neuroprotective agent for treatment of the injured nervous system. The repair of peripheral nerve injuries hinges on the proliferation and migration of Schwann cells, which play a crucial role in supporting axonal growth and myelination. In this study we synthesized Quercetin-derived carbon dots (QCDs) and investigated their effects on cultured Schwann cells and the NG108-15 cell line.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!