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BRACO-19 targeted the G-quadruplex in the 3'UTR of the Cucumber mosaic virus 1a, 2b, and CP genes to inhibit viral proliferation.
Pest Manag Sci
March 2025
National R&D Center for Se-rich Agricultural Products Processing, Hubei Engineering Research Center for Deep Processing of Green Se-rich Agricultural Products, School of Modern Industry for Selenium Science and Engineering, Wuhan Polytechnic University, Wuhan, China.
Background: The development of highly efficient and environmentally friendly plant virus inhibitors with novel structures mostly depends on the discovery of new targets. G-quadruplexes are non-classical high-level structures that are formed by guanine-rich nucleic acid sequences, which have significant biological functions. Small molecules that target the G-quadruplexes in the genomes of animal viruses have been shown to inhibit viral proliferation.
View Article and Find Full Text PDFSelective Degradation of Cucumber Mosaic Virus RNA3 by Nonsense-Mediated Decay Benefits Viral Early Infection.
Mol Plant Pathol
March 2025
College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China.
Nonsense-mediated mRNA decay (NMD) is a critical RNA quality control system in eukaryotes, also playing a role in defending against viral infections. However, research has primarily focused on nonsegmented viruses. To investigate the interaction between NMD and segmented RNA viruses, we used cucumber mosaic virus (CMV), which possesses a tripartite, single-stranded, positive-sense RNA genome.
View Article and Find Full Text PDFCucumber mosaic virus 2b directs fibrillarin translocation to plasmodesmata to promote viral movement.
New Phytol
March 2025
Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore, 117604, Singapore.
Detecting habitat preferences and monitoring population dynamics of sea cucumbers in coastal ecosystems through underwater photogrammetry.
J Environ Manage
March 2025
Department of Integrative Marine Ecology (EMI), Stazione Zoologica Anton Dohrn, Via Gregorio Allegri 1, 00198, Rome, Italy.
Sea cucumbers constitute common benthic organisms in the subtidal zones capable of providing key ecosystem services. Due to the recent harvesting and increased commercial interest in Mediterranean species, fundamental ecological knowledge is required to promote adequate management measures. In this regard, a remotely sensed mapping method is proposed for deriving length-frequency distribution and defining habitat preferences of a common sea cucumber species.
View Article and Find Full Text PDFAphis gossypii (Hemiptera: Aphididae) feeding responses to double virus infections in melon.
J Insect Sci
January 2025
Instituto de Ciencias Agrarias (ICA-CSIC), Madrid, Spain.
Virus infections cause economic losses in crops worldwide and their management and control present major challenges. In the field, double infections of two or more viruses are the rule, not the exception. The presence of several viruses in a plant makes it difficult to interpret virus-insect vector-plant interactions.
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