Tick-borne encephalitis (TBE) is a viral infection with variable clinical presentations, including neurological complications. We report a case of TBE in a 34-year-old farmer from an endemic region in Poland. The patient initially presented with paresis of the right brachial plexus. The diagnosis was challenging due to the absence of previous flu-like symptoms, often related to TBE infection. Neurological evaluations revealed paresis and muscle atrophy in the right upper limb, and serological tests confirmed TBE infection. Despite treatment efforts, neurological deficits persisted. This case highlights the need to consider TBE in the differential diagnosis of sudden-onset neurological disorders, especially in TBE-endemic regions, to ensure prompt intervention and prevent long-term complications.
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http://dx.doi.org/10.1155/crdi/7003058 | DOI Listing |
Cells
February 2025
Institute of Virology and Immunobiology, University of Würzburg, Versbacher Str. 7, 97078 Würzburg, Germany.
Cellular metabolism must adapt rapidly to environmental alterations and adjust nutrient uptake. Low glucose availability activates the AMP-dependent kinase (AMPK) pathway. We demonstrate that activation of AMPK or the downstream Unc-51-like autophagy-activating kinase (ULK1) inhibits receptor-mediated endocytosis.
View Article and Find Full Text PDFSci Rep
March 2025
Microbiologie, ADMED Analyses et Diagnostics Médicaux, La Chaux-de-Fonds, Switzerland.
Tick-borne encephalitis virus (TBEV) infection can manifest as disease of variable severity, ranging from subclinical infection to severe disease with neurological involvement and potentially fatal outcome. Although TBE is recognized as a major public health problem in Europe, the true burden of disease is potentially underestimated. Here, we investigated TBEV-specific antibody prevalence, infection incidence, and seroreversion and antibody decline rates in a prospective Swiss healthcare worker (HCW) cohort.
View Article and Find Full Text PDFActa Trop
March 2025
Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), Sede Territoriale di, Pavia, Italia. Electronic address:
The rising prevalence and transmission of tick-borne pathogens (TBPs) represent a significant public health issue all over the world, including in Italy. The region of Lombardy, in Northern Italy, is particularly endemic for TBPs. While evidence indicates a high exposure risk to infected ticks, there is a lack of data on ticks collected from humans.
View Article and Find Full Text PDFBackground: Alkhumra hemorrhagic fever virus is a newly discovered tick-borne flavivirus that was first identified in 1994 - 1995 in the Alkhumra district of Jeddah, Kingdom of Saudi Arabia. AHFV was detected in a butcher who developed severe hemorrhagic fever. Since then, a total of 604 confirmed cases have been reported in KSA between 1995 - 2020.
View Article and Find Full Text PDFHealth Promot Perspect
December 2024
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Background: Global warming is caused by increased carbon dioxide and other industrial gases, which shift the climate of human habitat and environment, impacting human health globally. In this review, we tried to overview the current knowledge of climate change's impact on neurological disease.
Methods: A comprehensive search on PubMed, Web of Science (WOS), and Scopus was conducted to find the relevant original studies.
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