The Lentiform Fork sign is an imaging finding on brain MRI described by bilateral, symmetric hyperintensities in the basal ganglia. It is described in the setting of metabolic acidosis of many etiologies and is a sign of vasogenic edema. Both imaging findings and symptoms are often reversible with correction of the acidosis and removal of any identifiable triggers. We report a case of confusion and ataxic gait in a patient with end stage renal disease and ongoing metformin use. The mechanism of metformin-induced encephalopathy remains unclear, but could be due to vulnerability of mitochondria to metformin within the lentiform nuclei.
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| http://dx.doi.org/10.56305/001c.127261 | DOI Listing |
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The Lentiform Fork sign is an imaging finding on brain MRI described by bilateral, symmetric hyperintensities in the basal ganglia. It is described in the setting of metabolic acidosis of many etiologies and is a sign of vasogenic edema. Both imaging findings and symptoms are often reversible with correction of the acidosis and removal of any identifiable triggers.
View Article and Find Full Text PDFUremic Encephalopathy Presented as Stroke: The Value of Lentiform Fork Sign.
Cureus
November 2024
Department of Radiology and Medical Imaging, King Abdulaziz Medical City, Riyadh, SAU.
Uremic encephalopathy (UE) is a neurological complication of renal failure characterized by cognitive dysfunction and movement abnormalities. A novel radiologic sign termed the "lentiform fork sign" has been identified in patients with UE and metabolic acidosis. This sign manifests as bilateral symmetrical hyperintensities in the basal ganglia, bordered by a hyperintense rim on magnetic resonance imaging (MRI), particularly on T2-weighted and fluid-attenuated inversion recovery (FLAIR) sequences.
View Article and Find Full Text PDFArticle Synopsis
- Posterior Reversible Encephalopathy Syndrome (PRES) can present atypically, sometimes seen as bilateral symmetrical vasogenic edema in the basal ganglia, noted as the "lentiform fork sign."
- Prompt identification of variations in PRES presentation is essential for accurate diagnosis and treatment, especially in transplant recipients using immunosuppressive drugs.
- A case study of a 19-year-old male highlights this atypical presentation and the importance of neuroimaging in diagnosing PRES, with successful management leading to resolution of symptoms within two weeks.
Magnetic Resonance Imaging in Uremic Encephalopathy: Identifying Key Imaging Patterns and Clinical Correlations.
J Clin Med
July 2024
Research Unit of Radiology, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 Roma, Italy.
Article Synopsis
- MRI is vital for diagnosing neurological disorders, particularly for identifying brain pathology in uremic encephalopathy (UE), a condition linked to kidney failure that causes cognitive impairment due to toxin buildup.* -
- Current research shows a lack of detailed MRI findings in UE, and the study seeks to establish correlations between specific MRI patterns and the severity of clinical symptoms to enhance diagnostic accuracy.* -
- The literature review revealed important MRI findings in UE, such as brain edema and key indicators like the "lentiform fork sign," highlighting the need for comprehensive diagnostic methods and better studies for improved treatment and understanding.*
"Lentiform fork sign" in uremic striatopallidal syndrome: a rare cause of parkinsonism.
Arq Neuropsiquiatr
August 2024
Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Neurociências e Ciências Comportamentais, Ribeirão Preto SP, Brazil.
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