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Department of Pathology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
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Mineral content of calcified tissues in cystic fibrosis mice.
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October 2001
Dalton Cardiovascular Research Center and the Department of Veterinary Biomedical Sciences, University of Missouri-Columbia, 65211, USA.
Although abnormal hard tissue mineralization is a recognized complication of cystic fibrosis (CF), the pathogenesis leading from the defective cystic fibrosis transmembrane conductance regulator (CFTR) protein is poorly understood. We hypothesized that CFTR plays a direct role in the mineralization of bone and teeth and tested the hypothesis using CF mouse models [CFTR(-) mice]. In vivo measurements by dual-emission X-ray absorpitometry (DEXA) indicated that bone mineral density (BMD) was reduced in CF mice as compared to gender-matched littermates.
View Article and Find Full Text PDFCorrelative Instrumental Neutron Activation Analysis, Light Microscopy, Transmission Electron Microscopy, and X-ray Microanalysis for Qualitative and Quantitative Detection of Colloidal Gold Spheres in Biological Specimens.
Microsc Microanal
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Department of Animal Health and Biomedical Sciences, University of Wisconsin-Madison, 1656 Linden Drive, Madison, WI 53706
: Colloidal gold, conjugated to ligands or antibodies, is routinely used as a label for the detection of cell structures by light (LM) and electron microscopy (EM). To date, several methods to count the number of colloidal gold labels have been employed with limited success. Instrumental neutron activation analysis (INAA), a physical method for the analysis of the elemental composition of materials, can be used to provide a quantitative index of gold accumulation in bulk specimens.
View Article and Find Full Text PDFIn vivo energy dispersive X-ray fluorescence for measuring the content of essential and toxic trace elements in teeth.
Appl Radiat Isot
February 1999
Medical Radiological Research Centre, Obninsk, Russia.
The calibration and application of a facility, based on energy dispersive X-ray fluorescent analysis (EDXRF) using 109Cd as an excitation source, for in vivo and in vitro estimation of Ca, Pb, Sr and Zn in tooth enamel is described. During the in vivo measurements, the device ensures tissue protection of face and mouth cavity from radiation, and only a small part of tooth surface under study is irradiated. To calibrate the facility, the contents of Ca, Sr and Zn were analyzed simultaneously in the enamel of 50 teeth by EDXRF and instrumental neutron activation analysis (INAA).
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