Tuberculosis (TB) can sometimes involve the central nervous system (CNS), especially among immunocompromised patients, but it is an infrequent manifestation. Among immunocompetent individuals, CNS TB has only scarcely been described in the literature; when it is manifested as a solitary lesion (tuberculoma), it can mimic other CNS tumors, appearing with clinical manifestations of increased intracranial pressure, such as headaches and vomiting. In this manuscript, we describe a case of a CNS tuberculoma, which presented as a cerebellum tumor with signs of increased intracranial pressure in an immunocompetent pregnant woman. Caesarian section and craniotomy with tumor excision were performed. Mycobacterium TB sensitive to rifampicin was identified in the tissue block, anti-TB treatment was initiated, and the patient's condition improved. The temporary immunosuppressive state of pregnancy may lead to the reactivation of TB infection, along with clinical manifestations from extrapulmonary sites, such as the CNS. Awareness of CNS tuberculomas and their clinical manifestations should be raised, as early recognition and treatment are important for a successful outcome.
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http://dx.doi.org/10.7759/cureus.78201 | DOI Listing |
PLoS One
March 2025
Instituto de Investigación en Zoonosis (CIZ), Universidad Central del Ecuador, Quito, Ecuador.
Anaplasmosis is a tick-borne disease (TBDs) caused by Anaplasma spp. In areas where TBDs are endemic, it is crucial to consider the animals' immunological status in relation to these diseases. The true prevalence of bovine anaplasmosis, the percentage of animals with protective antibodies against this TBD, and the diagnostic characteristics of three tests (multiplex polymerase chain reaction (mPCR), competitive-inhibition enzyme-linked immunosorbent assay (cELISA), and blood smear (BS)) were estimated using a Bayesian approach.
View Article and Find Full Text PDFAm J Clin Dermatol
March 2025
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Photoaging is the consequence of chronic exposure to solar irradiation, encompassing ultraviolet (UV), visible, and infrared wavelengths. Over time, this exposure causes cumulative damage, leading to both aesthetic changes and structural degradation of the skin. These effects manifest as rhytids, dyschromia, textural changes, elastosis, volume loss, telangiectasias, and hyperkeratosis, collectively contributing to a prematurely aged appearance that exceeds the skin's chronological age.
View Article and Find Full Text PDFJ Neurol
March 2025
Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China.
Objective: The aim of this study was to analyze the clinical characteristics of adult patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis combined with anti-myelin oligodendrocyte glycoprotein (MOG) antibodies.
Methods: This was a non-randomized controlled study. Clinical data were collected from 17 patients with anti-NMDAR encephalitis combined with anti-MOG antibodies admitted to Xuanwu Hospital, Capital Medical University, from January 2020 to August 2024.
Rheumatol Int
March 2025
Department of Rheumatology and Connective Tissue Diseases, Medical University, St. Jaczewskiego 8, 20-090, Lublin, Poland.
Pancreatic panniculitis (PP) and arthritis may be extrapancreatic manifestations of pancreatic disease. The triad of pancreatic disease, panniculitis and polyarthritis, described in the literature as the PPP syndrome, is sometimes observed in patients with acute or chronic pancreatitis, pancreatic cancer or neuroendocrine tumors (NETs). We present a 60-year-old man with polyarthritis and clinically aggressive PP of the limbs.
View Article and Find Full Text PDFJ Neurol
March 2025
Computational Neuroimaging Group (CNG), School of Medicine, Trinity College, Pearse Street, Dublin, Ireland.
Background: Pseudobulbar affect (PBA) is a well-recognised and troublesome clinical phenomenon in a range of neuroinflammatory, neoplastic, neurovascular and neurodegenerative conditions. It is often under-recognised in the community, frequently mistaken for psychiatric manifestations, appropriate pharmacological treatment is often delayed, and may result in a sense of embarrassment or lead to social isolation. Despite its considerable quality of life (QoL) implications and the challenges associated with its effective management, it is notoriously understudied.
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