Necrotizing infections of the head and neck are uncommon, aggressive, and potentially fatal if not treated promptly. These infections are particularly prevalent among immunocompromised individuals, such as people with diabetes, due to impaired immune response and delayed healing. We present a 45-year-old male with uncontrolled diabetes who had a five-day history of progressive left-sided neck swelling and pain. Imaging studies revealed an extensive necrotizing infection of the submandibular, parotid, and parapharyngeal carotid spaces. The condition was managed with intravenous antibiotics, ultrasound-guided aspiration, surgical drainage, extensive debridement, and skin grafting. The isolated microorganism was Klebsiella pneumoniae. After three weeks of management, the patient was discharged without impairment or recurrence. This case underscores the significance of early diagnosis, proper antibiotic use, timely surgery, and collaboration in managing neck space necrotizing infections to prevent complications in high-risk patients.
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