Basal cell carcinoma (BCC) is the most prevalent form of skin cancer; it is slow-growing and locally invasive with an extremely low likelihood of metastasis. The activation of the Hedgehog (HH) signaling pathway is implicated in nearly all cases, with ultraviolet radiation being the primary risk factor. While BCC typically occurs in areas of chronic sun exposure, it can rarely develop in non-sun-exposed areas, as demonstrated by our case of a 68-year-old Indian woman presenting with a BCC lesion on her left hip. Dermoscopy revealed features suggestive of basal cell carcinoma which was subsequently confirmed as adenoid type on histopathological examination. The patient underwent a successful wide excision of the lesion with clear margins, and post-operative healing was satisfactory. This case highlights the rare occurrence of BCC in non-sun-exposed areas and underscores the importance of early diagnosis and treatment. Regular follow-up is essential, as patients with a history of BCC are at high risk for subsequent skin cancers.
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http://dx.doi.org/10.7759/cureus.78259 | DOI Listing |
Dermatol Reports
February 2025
Unit of Melanoma, Cancer Immunotherapy and Innovative Therapies Unit, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Naples.
Basal cell carcinoma (BCC) is the most common malignant tumor in white populations. Multiple studies demonstrated that the aberrant activation of Hedgehog signaling is a driver of BCC development, and its blockade represents a potential therapeutic target. In Italy, clinicians can prescribe Hedgehog inhibitors (HhIs) vismodegib and sonidegib.
View Article and Find Full Text PDFEur J Cancer Prev
March 2025
Department of Oncology and Hemato-Oncology, University of Milan.
Endometriosis is one of the most common gynecological benign disease. Epidemiological evidence suggests a potential association between endometriosis and cancer risk. Accumulating evidence highlighted the risk of ovarian cancer, particularly endometrioid and clear cell subtypes.
View Article and Find Full Text PDFJ Craniofac Surg
March 2025
Department of Oculoplastic Surgery, Beijing Tongren Eye Center, Beijing Tongren Hospital; Beijing Key Laboratory of Ophthalmology and Visual Sciences, Capital Medical University, Beijing, China.
Study Design: Retrospective, noncomparative, and interventional case series.
Objective: Peripunctal tumors are uncommonly encountered. The management at the aesthetically and functionally sensitive area is demanding.
Cell Transplant
March 2025
Cardiovascular Research Unit, IRCCS MultiMedica, Milan, Italy.
Diabetic foot ulcers (DFUs) are associated with a high risk of amputations and a 50% 5-year survival rate due at least in part to the limited angiogenic and wound healing capacity of patients with diabetes. Cell therapy via intramuscular injection of peripheral blood mononuclear cells showed encouraging but limited results. Such limitations may arise from the limited ability of therapeutic cells to adhere to the target tissue.
View Article and Find Full Text PDFEur J Histochem
January 2025
Institute of Tissue Medicine and Pathology; Graduate School for Cellular and Biomedical Sciences, University of Bern.
Accurate differentiation of homologous proteins that share high sequence identity remains a significant challenge in biomedical research, as conventional antibodies often lack sufficient specificity, leading to potential misinterpretations. This issue is particularly evident in the study of hexokinases, a family of isoenzymes that catalyze the first step of glycolysis by phosphorylating glucose. Beyond their canonical metabolic roles, hexokinases play critical non-glycolytic functions, especially in cancer biology.
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