The advent of Generative Artificial Intelligence (Generative AI or GAI) marks a significant inflection point in AI development. Long viewed as the epitome of reasoning and logic, Generative AI incorporates programming rules that are normative. However, it also has a descriptive component based on its programmers' subjective preferences and any discrepancies in the underlying data. Generative AI generates both truth and falsehood, supports both ethical and unethical decisions, and is neither transparent nor accountable. These factors pose clear risks to optimal decision-making in complex health services such as health policy and health regulation. It is important to examine how Generative AI makes decisions both from a rational, normative perspective and from a descriptive point of view to ensure an ethical approach to Generative AI design, engineering, and use. The objective is to provide a rapid review that identifies and maps attributes reported in the literature that influence Generative AI decision-making in complex health services. This review provides a clear, reproducible methodology that is reported in accordance with a recognised framework and Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 standards adapted for a rapid review. Inclusion and exclusion criteria were developed, and a database search was undertaken within four search systems: ProQuest, Scopus, Web of Science, and Google Scholar. The results include articles published in 2023 and early 2024. A total of 1,550 articles were identified. After removing duplicates, 1,532 articles remained. Of these, 1,511 articles were excluded based on the selection criteria and a total of 21 articles were selected for analysis. Learning, understanding, and bias were the most frequently mentioned Generative AI attributes. Generative AI brings the promise of advanced automation, but carries significant risk. Learning and pattern recognition are helpful, but the lack of a moral compass, empathy, consideration for privacy, and a propensity for bias and hallucination are detrimental to good decision-making. The results suggest that there is, perhaps, more work to be done before Generative AI can be applied to complex health services.
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http://dx.doi.org/10.7759/cureus.78257 | DOI Listing |
Bone Joint Res
March 2025
Department of Orthopedics, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou, China.
Aims: Osteoarthritis (OA) is a widespread chronic degenerative joint disease with an increasing global impact. The pathogenesis of OA involves complex interactions between genetic and environmental factors. Despite this, the specific genetic mechanisms underlying OA remain only partially understood, hindering the development of targeted therapeutic strategies.
View Article and Find Full Text PDFNanomedicine (Lond)
March 2025
Department of Chemistry and The Institute for Laser, Photonics, and Biophotonics, University at Buffalo, The State University of New York, Buffalo, NY, USA.
Background: Nanomedicine offers a number of innovative strategies to address major public health burdens, including complex respiratory illnesses. In this work, we introduce a multi-drug nanoparticle fabricated using femtosecond laser ablation for the treatment of influenza, SARS-CoV-2, and their co-infections.
Methods: The SARS-CoV-2 antiviral, remdesivir; the influenza antiviral, baloxavir marboxil; and the anti-inflammatory, dexamethasone, were co-crystalized and then ablated in aqueous media using a femtosecond pulsed laser and subsequently surface modified with the cationic polymer, chitosan, or poly-d-lysine.
Phys Ther
March 2025
Doctor of Physical Therapy Program, Nova Southeastern University, Tampa Bay Regional Campus, Clearwater, FL 33759, United States.
Objective: The prevalence of students with disabilities in physical therapist education programs in the United States is <1%. This case report explored the experiences surrounding a specific, unique individual student with blindness or visual impairment (BVI) within the context of an entry-level physical therapist program. The purpose was not merely to describe 1 student's journey but to capture the complex dynamics and shifts in perceptions of students, faculty, staff, and clinicians.
View Article and Find Full Text PDFBiol Reprod
March 2025
Cell Biology Laboratory, Research Institute for Biosciences, Research Institute for Health Sciences and Technology, University of Mons, Mons, Belgium.
CRISP2 is enriched in the male reproductive system of mammals and plays roles in spermatogenesis, sperm motility, and fertilization. Although extensively investigated in rodents and boars, human CRISP2 (hCRISP2) remains poorly studied, particularly concerning its localization in testicular and epididymal tissues and its molecular features. In this study, we used immunofluorescence to determine the localization of hCRISP2 in testis, epididymis, and ejaculated sperm.
View Article and Find Full Text PDFPublic Health Nutr
March 2025
Department of Geography, Faculty of Social Science, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
China has dedicated significant efforts to preventing obesity, but the rising prevalence of overweight and obesity remains a pressing public health issue. Therefore, unique solutions are required to address this challenge in China. As a research priority, the food environment plays a pivotal role in addressing overweight and obesity.
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