Inappropriate penicillin allergy labeling results in suboptimal or excessive broad spectrum antibiotic use. In this multidisciplinary project, the antimicrobial stewardship team safely delabeled 71.4% of hospitalized patients approached. Similar programs may also be able to delabel minimal or low-risk penicillin allergic patients without formal allergy consultation.
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http://dx.doi.org/10.1017/ash.2025.7 | DOI Listing |
Pediatr Infect Dis J
March 2025
Divisions of Pediatric Emergency Medicine and Pediatric Infectious Diseases, Baylor College of Medicine, Houston, Texas.
Background: Infection is a leading cause of death after pediatric heart transplants (PHTs). Understanding of common pathogens is needed to guide testing strategies and empiric antibiotic use.
Methods: We conducted a 3-center retrospective study of PHT recipients ≤18 years old presenting to cardiology clinics or emergency departments (EDs) from 2010 to 2018 for evaluation of suspected infections within 2 years of transplant.
Indian J Gastroenterol
March 2025
Departments of Pediatrics, Giza, Egypt.
Background And Objectives: Kasai-portoenterostomy (KPE) is the initial attempt to restore the bile flow and salvage the native liver in biliary atresia (BA) patients. Cholangitis is a frequent complication after KPE and adequate treatment impacts the long-term outcome. The aim of our study is to assess the severity of cholangitis episodes in a cohort of BA patients post KPE, identify the causative agents, using several diagnostic methods, as well as to assess the tolerability and efficacy of our antimicrobial protocol.
View Article and Find Full Text PDFMycoses
March 2025
Department I of Internal Medicine, European Diamond Excellence Centre for Medical Mycology (ECMM), and Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf (ABCD), Cologne, Germany.
Candidaemia in children is associated with high mortality. The epidemiology of Candida bloodstream infection is changing with rising rates of fluconazole resistance worldwide and the emergence of novel multidrug-resistant species such as Candida auris, which is associated with outbreaks. Guidelines on the management of candidaemia emphasise identification of species and determination of antifungal susceptibility to guide appropriate treatment, performing relevant investigations to rule out deep-seated infection, and removal of central venous catheters.
View Article and Find Full Text PDFInt J Antimicrob Agents
March 2025
Department of Epidemiology and Preventive Medicine, Office of Clinical Epidemiology, Analytics, and Knowledge, Tan Tock Seng Hospital, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore. Electronic address:
Antibiotic use in pets can contribute to antimicrobial resistance (AMR) in both humans and pets. There is a paucity of data on pet owners' knowledge, attitudes, and practices regarding antibiotic use in pets in Asia, despite increasing pet ownership. Therefore, we conducted a study to compare the knowledge, attitudes and practices of antibiotic use and AMR for pets amongst cat and/or dog owners in Singapore.
View Article and Find Full Text PDFAntimicrobial resistance is a critical global health challenge, requiring effective strategies to promote rational antimicrobial prescribing among healthcare professionals. This study investigates how social support mediates prescribing behavior through psychosocial factors, providing insights into healthcare decision-making. A cross-sectional survey of 720 healthcare professionals was conducted, and Structural Equation Modeling (SEM) was used to evaluate the mediating roles of self-efficacy, knowledge and skills, and health beliefs.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!