There is a lack of consensus and uniformity about the test dose in epidurals for labor analgesia. We, therefore, conducted a questionnaire-based survey to assess the current practice in India regarding test-dose for labor epidurals among practicing obstetric anesthetists. A Google form based questionnaire was circulated to 300 members of the Association of Obstetric Anesthesiologists (AOA) of India of which 128 (42.7%) responded. According to our survey, labor analgesia is routinely practiced by only 40 (32%) responders. Sixty-eight (53.1%) responders reported placement of an epidural catheter at the patient's request. Less than 50% reported the use of test dose for epidural catheter placement confirmation. Ninety-eight (76.6%) responders give the test dose at the time of catheter placement while 22 (17.1%) give it every time before injecting the local anesthetic as a top-up. The majority preferred using 3-4 mL of 2% lidocaine as test dose. Seventy-three (57%) responders relied on the use of conventional test dose of lidocaine with epinephrine. 8.5% of responders had experienced side effects with epidural test dose during labor analgesia. This survey highlights not just variations in the clinical practice regarding epidural test dose for labor analgesia but gross deviation from the current recommended standard of practice. The issue can be addressed by developing clear practice guidelines.
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http://dx.doi.org/10.4103/joacp.joacp_353_23 | DOI Listing |
BJGP Open
March 2025
Department of clinical pharmacy, Canisius Wilhelmina Hospital, Utrecht University, Utrecht, The Netherlands
Background: Quetiapine, an antipsychotic, is registered for schizophrenia, bipolar disorder, and as an add-on therapy for major depressive disorder. Its anxiolytic and sedative effects make it attractive for off-label uses like insomnia, despite cardiovascular and metabolic side effects. The global increase in quetiapine use over the past decade warrants an examination of its prescribing patterns, especially off-label.
View Article and Find Full Text PDFBMJ Open
March 2025
School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Objectives: To describe the prevalence and patterns of opioid analgesic and pain medicine dispenses, and the impact of up-scheduling of low-dose (≤15 mg) codeine-containing products to Australians with accepted workers' compensation time loss claims for musculoskeletal conditions between 2010 and 2019.
Design: Interrupted time series.
Setting: Workers' compensation scheme in Victoria, Australia.
Int J Pharm
March 2025
New Jersey Institute of Technology, Otto H. York Department of Chemical and Materials EngineeringNewark, NJ 07102-1982, USA. Electronic address:
Small volume dissolution systems are commonly used in dissolution testing, primarily in method development for low dose formulations compared to standard dissolution apparatuses used with evaluation of larger formulations. This is typically done because of cost savings associated with using smaller media volumes and sample sizes, to overcome the lack of material in early development, and to provide higher analytical sensitivity and discrimination ability. The Chinese Pharmacopoeia (CP) includes a small dissolution apparatus in their list ("Method 3 (Small Vessel)") (The State Pharmacopoeia Commission of P.
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Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; National Centre for Infectious Diseases, Singapore; Duke-NUS Graduate Medical School, National University of Singapore, Singapore; Department of Infectious Diseases, Singapore General Hospital, Singapore. Electronic address:
Background: Significant heterogeneity has been reported in estimates of long-term sequelae following SARS-CoV-2 infection in pregnant women, and most studies were conducted pre-Omicron and pre-dated vaccination rollout. Less severe COVID-19 attributed to milder Omicron may potentially attenuate risk of post-COVID-19 sequelae.
Objective: We sought to examine long-term risk of new-incident multi-systemic sequelae following SARS-CoV-2 Delta/Omicron infection in a population-based cohort of pregnant women, contrasted against a)test-negatives; b)infected non-pregnant women of childbearing age.
Poult Sci
March 2025
INRAE, UMR ISP, Université de Tours, Nouzilly 37380, France. Electronic address:
Avian coccidiosis, caused by Eimeria spp., is the main parasitic disease in the poultry industry, responsible for high economic costs worldwide. Faced with anticoccidial resistance and societal pressure to reduce inputs in livestock sector, insects could provide a relevant alternative to anticoccidial molecules.
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