We report a case of a 76-year-old female with stage 4 chronic kidney disease (CKD) who experienced multiple adverse events following the initiation of colchicine for a gout flare. Diarrhea led to further complications, including acute renal failure, hypercalcemia, and bradycardia. The patient additionally developed the less common toxicities of myelosuppression and presumed myopathy, resulting in prolonged hospitalization with persistent functional impairment at the time of discharge. This report highlights the importance of exercising caution when prescribing colchicine to patients with severe CKD. It discusses alternate ways to manage acute gout as well as strategies to minimize the risk of adverse events when using colchicine in this population.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864489 | PMC |
| http://dx.doi.org/10.56305/001c.123647 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prevalence and Factors Associated With Hepatitis C Virus in Riyadh, Saudi Arabia: A Large Cross-Sectional Study.
J Epidemiol Glob Health
March 2025
Department of Public Health, College of Public Health and Health Informatics, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Introduction: Viral hepatitis stands accountable for approximately 1.34 million deaths worldwide, with the number of fatalities steadily growing with time. This is partly due to the various genotypes of hepatitis C virus and having no vaccination developed yet.
View Article and Find Full Text PDFNative potential probiotics and postbiotics improve the gut-kidney axis by the modulation of autophagy signaling pathway.
Folia Microbiol (Praha)
March 2025
Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran.
The gut-kidney axis is the bidirectional relationship between the gut microbiota and the kidney function. Chronic inflammatory responses can impair kidney function and probiotics and postbiotics agents can have positive effects on gut health and kidney function by modulating inflammation through affecting autophagy signaling pathway. The aim of the current study was to evaluate the properties of our probiotic and postbiotics to improve kidney health by focusing the autophagy signaling pathway.
View Article and Find Full Text PDFVancomycin- induced leukocytoclastic vasculitis in a patient with end-stage renal disease: a case report and literature review.
Daru
March 2025
Thoracic Research Center, Imam Khomeini, Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Introduction: Leukocytoclastic vasculitis (LCV) is a small-vessel inflammatory condition that can rarely occur as an adverse drug reaction (ADR). Vancomycin-induced LCV is an uncommon but potentially serious complication, particularly in patients with pre-existing renal impairment.
Reason For The Report: This case report describes a patient with end-stage renal disease (ESRD) who developed LCV following vancomycin therapy for a catheter-related infection.
Plant-Based Diets Across the Spectrum of Kidney Disease.
Clin J Am Soc Nephrol
March 2025
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
Diet is gaining traction as a major chronic kidney disease (CKD)-related risk factor for death and disability. Furthermore, a "healthy" diet in patients with CKD is associated with reduced mortality. The data to be discussed support diet as the foundational, "food integrated with pharmacologic therapy," approach to management of individuals with CKD and those at risk for it.
View Article and Find Full Text PDFAirborne particulate matter exposure in male sugarcane workers at risk for chronic kidney disease in Guatemala.
Ann Work Expo Health
March 2025
Department of Environmental and Occupational Health (EOH), Colorado School of Public Health, University of Colorado Anschutz Campus, 13001 E. 17th Place, Mail Stop B119, Aurora, CO 80045, United States.
Background: There is an international epidemic of chronic kidney disease of unknown cause (CKDu) in agricultural working populations. Particulate air pollution is a likely contributing factor in populations at risk for CKDu, but there is little personal breathing zone data for these workers.
Methods: We collected 1 to 3 personal breathing zone particulate matter <5 microns (PM5) gravimetric measurements in 143 male sugarcane harvesters over 2 seasons and concurrent ambient samples using personal sampling pumps and cyclone inlets as a sampling train.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!