Fundamental science can sometimes take a long time until it is useful for practical applications, as was the case for Raman spectroscopy. For a long time, it lacked powerful excitation sources and sensitive detectors. However as technology evolved, the number of exciting applications has boomed. Modern Raman spectroscopy has significant advantages, especially in sample preparation. Handheld Raman devices can be very compact and therefore be easily taken to the sample instead of bringing the sample to the lab. Non-destructive measurements obviously are important in gemmology and mineralogy, even in space. In the field of archaeology, pigments in precious ancient paintings, scrolls or books can be identified. This application is also used to identify fraud and falsification and in studies from a medical school they have reported that Raman spectroscopy can be applied to distinguish cancerous tissue from healthy tissue. Due to the mobility and ruggedness of the handheld hardware, Raman spectroscopy can be used for police, firefighters, and military applications for identification of explosives and illicit drugs or warfare substances. With SERS (Surface Enhanced Raman Spectroscopy), Raman spectroscopy can even be used for trace analysis. The SERS effect enhances the sensitivity of the Raman signal by a factor of up to 107. This enables, for example, measuring pesticide residuals on fruit or vegetable surfaces for food safety. It can also be used to identify traces of drugs, e.g. in urine. However, one of the most common Raman-applications is the identity check or verification of incoming goods (RMID) in the pharma industries, directly in the warehouse. Users appreciate the ease of use and the ruggedness of the Raman hardware.
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http://dx.doi.org/10.2533/chimia.2025.46 | DOI Listing |
Anal Chim Acta
May 2025
Department of Nephrology, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, Zhejiang, PR China. Electronic address:
The sensitive, efficient, and simultaneous assay of creatinine and urea in different body fluid is crucial for the daily detection and treatment of chronic kidney disease. Here, we exploited a versatile composite surface enhanced Raman scattering (SERS) substrate of polydimethylsiloxane (PDMS)-flower-like ZIF-67@Ag nanoparticles (NPs) based on simple in-situ growth and ion sputtering strategies. The plasmonic Ag NPs assembled on the three-dimensional anisotropic ZIF-67 matrix, facilitating numerous resonant electromagnetic "hotspots".
View Article and Find Full Text PDFJ AOAC Int
March 2025
Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, K1S 5B6 Canada.
Background: Plant-based milk alternatives (PBMA) are increasingly popular due to rising lactose intolerance and environmental concerns over traditional dairy products. However, limited efforts have been made to develop rapid authentication methods to verify their biological origin.
Objective: In this study, we developed a rapid, on-site analytical method for the authentication and identification of PBMA made by six different plant species utilizing a portable Raman spectrometer coupled with machine learning.
Food Funct
March 2025
College of Food Science and Engineering, Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, China.
Lactoferrin (LF) and epigallocatechin gallate (EGCG) are recognized for their potent osteogenic properties. However, the osteogenic activity of LF-EGCG complexes is not fully understood. In this study, both non-covalent and covalent LF-EGCG complexes with different LF : EGCG ratios were prepared, and their effects on the LF structure and thermal stability were investigated using circular dichroism, Fourier transform infrared spectroscopy, fluorescence spectroscopy, Raman spectroscopy, and differential scanning calorimetry.
View Article and Find Full Text PDFNanoscale
March 2025
School of Physics and Optoelectronics, South China University of Technology, Guangzhou 510640, China.
Raman spectroscopy has demonstrated significant potential in molecular detection, analysis, and identification, particularly when it adopts single-molecule surface-enhanced Raman scattering (SM-SERS) substrates. A recent SM-SERS scheme incorporates two-fold Raman enhancement mechanisms: the electromagnetic enhancement enabled by a plasmonic nanogap hotspot formed from gold sphere nanoparticles sitting on a gold mirror and the chemical enhancement enabled by a two-dimensional material, WS, inserted into the nanogap. In this work we integrate multiple advanced concepts and techniques to achieve remarkable performance improvements of SM-SERS.
View Article and Find Full Text PDFACS Appl Mater Interfaces
March 2025
Northwest Institute for Nonferrous Metal Research, Xi'an, Shannxi 710016, China.
Porous KTi(PO) nanoparticles are synthesized via a solvothermal method and subsequently modified with nitrogen-doped carbon layers by using polydopamine as the carbon source. The resultant KTi(PO)@N-doped carbon composite (KTP@NC) exhibits a preserved porous structure with abundant pores, facilitating ion diffusion and electrolyte infiltration. Various characterizations, including X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and Raman spectroscopy, reveal the successful formation of an interconnected nitrogen-doped carbon network.
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