Betulinic acid isolated from Platanus orientalis bark was modified in a one pot reaction to furnish twelve urea derivatives.The synthesized derivatives were tested against an array of cancer cell lines, colon HCT-116, breast MCF-7, pancreatic MIA PaCa-2 and prostate PC-3 cancer cell lines. Among the synthesized compounds BA1 exhibited potent anti-cancer activity with IC50 of 0.84 µM and 3.87 µM against HCT-116 and PC-3 using doxorubicin as standard. Our study demonstrate anti-proliferative and anti-metastatic role of BA1 thus, inducing apoptosis in prostrate and colorectal cell lines. Keywords Betulinic acid • urea • colorectal cancer• prostate cancer • apoptosis.
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