Cervical cancer, arising from the cells of the cervix, the lower segment of the uterus connected to the vagina-poses a significant health threat. The microscopic examination of cervical cells using Pap smear techniques plays a crucial role in identifying potential cancerous alterations. While developed nations demonstrate commendable efficiency in Pap smear acquisition, the process remains laborious and time-intensive. Conversely, in less developed regions, there is a pressing need for streamlined, computer-aided methodologies for the pre-analysis and treatment of cervical cancer. This study focuses on the classification of squamous cells into five distinct classes, providing a nuanced assessment of cervical cancer severity. Utilizing a dataset comprising over 4096 images from SimpakMed, available on Kaggle, we employed ensemble technique which included the Convolutional Neural Network (CNN), AlexNet, and SqueezeNet for image classification, achieving accuracies of 90.8%, 92%, and 91% respectively. Particularly noteworthy is the proposed ensemble technique, which surpasses individual model performances, achieving an impressive accuracy of 94%. This ensemble approach underscores the efficacy of our method in precise squamous cell classification and, consequently, in gauging the severity of cervical cancer. The results represent a promising advancement in the development of more efficient diagnostic tools for cervical cancer in resource-constrained settings.
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http://dx.doi.org/10.1038/s41598-025-91786-3 | DOI Listing |
J Clin Exp Hematop
March 2025
Department of Diagnostic Pathology and Cytology, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka-city, Osaka, Japan.
Kimura disease (KD) is a rare chronic inflammatory condition that primarily affects Asian males and typically presents in the head and neck region. We describe an exceptionally rare case of KD involving the lingual tonsil of Waldeyer's ring in a 39-year-old Japanese man, marking only the second reported instance of lingual involvement and the first specifically affecting the tongue base. The patient presented with a well-circumscribed, 3.
View Article and Find Full Text PDFKeio J Med
March 2025
Center for Hereditary Breast and Ovarian Cancer Syndrome, Keio University Hospital, Tokyo, Japan.
Hereditary breast and ovarian cancer syndrome (HBOC) is traditionally associated with mutations in the BRCA1 and BRCA2 genes, predominantly impacting breast, ovarian, pancreatic, and prostate cancers. However, recent research suggests that these mutations may also predispose carriers to a broader spectrum of malignancies, including biliary tract, cervical, colorectal, endometrial, esophageal, and gastric cancers. This review presents findings from extensive datasets, including a significant study from a nationwide Japanese biobank that examined cancer risks in 63,828 patients and 37,086 controls.
View Article and Find Full Text PDFZhong Nan Da Xue Xue Bao Yi Xue Ban
October 2024
Department of Pharmaceutical Engineering, Chemistry and Chemical Engineering, Central South University, Changsha 410083.
Objectives: Small interfering RNA (siRNA) can silence disease-related genes through sequence-specific RNA interference (RNAi). Cationic lipid-based liposomes effectively deliver nucleic acids into the cytoplasm but often exhibit significant toxicity. This study aims to synthesize a novel ionizable lipid, Nε-laruoyl-lysine amide (LKA), from natural amino acids, constructed LKA-based liposomes, and perform physicochemical characterization and cell-based experiments to systematically evaluate the potential of these ionizable lipid-based liposomes for nucleic acid delivery.
View Article and Find Full Text PDFOccup Environ Med
March 2025
Research Directorate, Veterans Affairs Canada, Charlottetown, Prince Edward Island, Canada
Objectives: To describe rates of overall and type-specific primary cancers in Canadian Armed Forces (CAF) personnel and Veterans with a first enrolment in the CAF between 1976 and 2016, with comparisons to the Canadian general population (CGP).
Methods: This retrospective cohort study linked CAF administrative data to national cancer registries. Primary cancer diagnoses were ascertained from 1976 to 2017.
Phys Med Biol
March 2025
Faculty of Business Information, Shanghai Business School, 123 Fengpu Blvd, Shanghai, 201499, CHINA.
: Radiotherapy planning requires significant expertise to balance tumor control and organ-at-risk (OAR) sparing. Automated planning can improve both efficiency and quality. This study introduces GPT-Plan, a novel multi-agent system powered by the GPT-4 family of large language models (LLMs), for automating the iterative radiotherapy plan optimization.
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