Anti-synthetase syndrome (ASyS) is a subset of idiopathic inflammatory myopathies characterized by a triad of myositis, interstitial lung disease, and arthritis. Patients with ASyS are generally treated with glucocorticoids, immunosuppressants, or both. We encountered a 53-year-old woman who developed anti-OJ autoantibodies-positive anti-synthetase syndrome following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and Cov-2 messenger RNA (mRNA) vaccination. Her dyspnea and rash resolved within 4 weeks of the initial examination, achieving spontaneous remission without treatment 52 weeks after the diagnosis. This case suggests a potential association between SARS-CoV-2 infection, mRNA vaccination, and the transient development of anti-OJ antibodies-positive ASyS.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2169/internalmedicine.4852-24 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Distinct Cytokine and Cytokine Receptor Expression Patterns Characterize Different Forms of Myositis.
medRxiv
February 2025
Muscle Disease Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Objective: Myositis is a heterogeneous family of inflammatory myopathies. We sought to define the differential expression of cytokines, cytokine receptors, and immune checkpoint genes in muscle biopsies from patients with different forms of myositis in order to characterize patterns of inflammation in each.
Methods: Bulk RNA sequencing was performed on muscle biopsy samples from 669 patients, including 105 with dermatomyositis, 80 with immune-mediated necrotizing myopathy (IMNM), 65 with anti-synthetase syndrome, 53 with inclusion body myositis (IBM), 19 with anti-PM/Scl myositis, 310 with other inflammatory or genetic myopathies, and 37 controls with normal tissue (NT).
Spontaneous Remission in a Patient with Anti-OJ Autoantibodies-positive Anti-synthetase Syndrome Following SARS-CoV-2 Infection and mRNA Vaccination: A Case Report.
Intern Med
March 2025
First Department of Internal Medicine, University of Occupational and Environmental Health, Japan.
Anti-synthetase syndrome (ASyS) is a subset of idiopathic inflammatory myopathies characterized by a triad of myositis, interstitial lung disease, and arthritis. Patients with ASyS are generally treated with glucocorticoids, immunosuppressants, or both. We encountered a 53-year-old woman who developed anti-OJ autoantibodies-positive anti-synthetase syndrome following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and Cov-2 messenger RNA (mRNA) vaccination.
View Article and Find Full Text PDFThrombotic microangiopathy as a presentation of anti-synthetase syndrome.
Lancet Rheumatol
February 2025
Department of Rheumatology, Key Laboratory of Myositis, China-Japan Friendship Hospital, Beijing, China. Electronic address:
Flexor Tenosynovitis as the Sole Initial Presentation of Anti-synthetase Syndrome: A Case Report.
Cureus
January 2025
Rheumatology, University of Central Florida College of Medicine, Orlando, USA.
Anti-synthetase syndrome (ASS) is a rare autoimmune disorder characterized by interstitial lung disease (ILD), myositis, and arthritis, primarily associated with antibodies, such as anti-Jo-1, that target the t-ribonucleic acid (tRNA) synthetase enzymes. This case report describes a 45-year-old man who presented with isolated flexor tenosynovitis and bilateral hand pain, later diagnosed with anti-Jo-1 positive ASS. Initially, the patient's symptoms were attributed to a trivial injury, but subsequent imaging and laboratory evaluations revealed tenosynovitis without signs of inflammatory arthritis.
View Article and Find Full Text PDFUltrasensitive interferons quantification reveals different cytokine profile secretion in inflammatory myopathies and can serve as biomarkers of activity in dermatomyositis.
Front Immunol
February 2025
Department of Internal Medicine and Clinical Immunology, National Reference Center for Rare NeuroMuscular Disorders, Pitié-Salpêtrière Hospital, Paris, France.
Objective: The objective of this study was to evaluate the presence of different types of interferon in idiopathic inflammatory myopathies (IIM) and their subgroups using ultrasensitive cytokine detection techniques (SIMOA) and to assess their potential as activity biomarkers.
Methods: Disease activity was measured at the time of serum collection and assessed by manual muscle testing eight (MMT8 score 0-150), muscle enzymes to calculate the Physician Global Assessment (PGA) (0-10). Patients were classified as active if PGA>5.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!