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The thyroid is essential for the metabolic processes in the body, and its imbalance can cause acute and chronic health issues. Autoimmune thyroid disease includes both Hashimoto's thyroiditis (HT) and Graves' disease (GD). HT is the most common cause of hypothyroidism, while GD is the most common cause of hyperthyroidism.
View Article and Find Full Text PDFCases of high-consequence infectious diseases identified in the UK, 1962-2023.
J Med Microbiol
March 2025
NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, UK.
The management of patients with acute infectious diseases can present significant challenges, especially if the causative agent has a propensity for person-to-person transmission. In such cases, effective patient management is dependent on both rapid identification of disease and the provision of necessary medical care while adhering to suitable infection prevention and control measures to reduce the potential for onwards transmission. The UK has operated a defined system for managing patients with high-consequence infectious diseases (HCIDs) since the 1970s, when protocols were first implemented following the first descriptions of several viral haemorrhagic fever diseases, including Marburg virus disease, Lassa fever and Ebola virus disease (EVD).
View Article and Find Full Text PDFSomatic Genomic Alterations in Haematological Tumours Can Interfere With Accurate HLA and Chimerism Diagnostics.
HLA
March 2025
Department of Transplantation Immunology, Maastricht University Medical Center, Maastricht, the Netherlands.
Tumour cells, which are often found in the peripheral blood of patients with acute leukaemia, may harbour multiple somatic alterations throughout the genome, including changes in the HLA region and short tandem repeat (STR) regions. We investigated whether such somatic alterations interfere with HLA and chimerism diagnostics conducted in preparation for an allogeneic haematopoietic stem cell transplantation (allo-HSCT). This study describes 10 patient-based cases for which laboratory diagnostics were performed prior to a possible stem cell transplant in the Maastricht University Medical Center.
View Article and Find Full Text PDF[Atelectasis caused by mucus stasis].
Ned Tijdschr Geneeskd
March 2025
Zaans Medisch Centrum, afd. Intensive Care, Zaandam.
A 58-year-old female presented at the emergency department with dyspnea. Laboratory and X-ray analyses showed eosinophilia and a partial atelectasis of the left lung, respectively. Bronchoscopy demonstrated mucus plugs.
View Article and Find Full Text PDFCase of endocarditis triggering both ischemic and haemorrhagic stroke: A rare clinical presentation from eastern India.
Infez Med
March 2025
Department of Microbiology, All India Institute of Medical Sciences, Kalyani, India.
We report a rare clinical presentation of a 54-year-old male diagnosed with infective endocarditis caused by , a nutritionally variant streptococcus (NVS) characterized by unique growth requirements and high pathogenic potential. The patient presented with prolonged fever and residual hemiparesis following an ischemic stroke. Blood culture confirmed , and imaging identified vegetations on a bicuspid aortic valve.
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