Introduction: Clinical guidelines recommend a holistic approach to Parkinson's disease (PD) care, yet randomized trials examining mindfulness-based interventions in this context are scarce. This study investigated the effects of two mindfulness practices - meditation and yoga - on biopsychosocial outcomes in PD patients, including anxiety symptoms, depressive symptoms, motor/nonmotor symptoms, health-related quality-of-life (HRQOL), mindfulness, and stress and inflammation biomarkers, compared to usual care.
Methods: 159 participants with a clinical diagnosis of idiopathic PD and a Hoehn and Yahr stage of 1, 2, and 3, were randomized into meditation (n = 53), yoga (n = 52), and control (n = 54). Meditation and yoga were delivered in 90-min groups for 8 weeks. Primary outcomes included anxiety symptoms and depressive symptoms. Secondary outcomes included motor and nonmotor symptoms, HRQOL, mindfulness, and serum levels of interleukin-6, cortisol and TNF-alpha. Assessments were done at baseline (T0), 2 months (T1), and 6 months (T2). Linear mixed models were conducted following intention-to-treat principle.
Results: Compared to control, both meditation, and yoga groups had significant improvements in anxiety symptoms (meditation: mean difference [MD] = -1.36, 95% CI: -2.46 to-0.26; yoga: MD = -1.61, CI: -2.70 to -0.52), motor symptoms (meditation: MD = -5.35, CI: -8.61 to-2.09; yoga: MD = -6.59, CI: -9.82 to-3.36), HRQOL (meditation: MD = -2.01, CI: -3.41 to-0.62; yoga: MD = -1.45, CI: -2.83 to-0.08), and describing skills (meditation: MD = 0.97, CI: 0.04-1.89; yoga: MD = 0.92, CI: 0.01-1.84) at T1, and significant reductions in serum interleukin-6 levels (meditation: MD = -1.14, CI: -2.18 to-0.10; yoga: MD = -1.11, CI: -2.09 to-0.13) at T2. Only meditation significantly reduced depression (MD = -1.44, CI: -2.57 to-0.30) at T1 and sustained the motor and HRQOL improvements at T2.
Conclusion: Meditation and yoga significantly improved anxiety symptoms, chronic inflammation, motor symptoms, mindfulness-describing facet, and HRQOL in PD patients. Meditation provided additional benefits in reducing depressive symptoms and sustaining motor and HRQOL improvements.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000543457 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: Yoga is an ancient lifestyle practice and science of the spiritual realm. According to the philosophy of yoga, the most sacred syllable of chanting is Om. Despite ample evidence on the effect of Om chanting on several physiologic variables, there is no comprehensive review of Om chanting and its effect on various systems of the body.
View Article and Find Full Text PDFLong-term effects of yoga-based practices on neural, cognitive, psychological, and physiological outcomes in adults: a scoping review and evidence map.
BMC Complement Med Ther
March 2025
Department of Basic Psychological Processes, Institute of Psychology, University of Brasilia, Brasilia, Brazil.
Background: Compared with short-term practices, long-term yoga might promote differential qualitative and quantitative outcomes. Following JBI's and PRISMA-ScR guidelines, this scoping review followed an apriori and systematic protocol to document the long-term effects of yoga on neural, cognitive, psychological, and physiological outcomes, provide evidence maps for each yoga component, and summarize results identifying knowledge gaps and promising directions.
Methods: Four databases (PubMed, Cochrane, LILACS, and PubPsych) were last searched in March 2023.
Spiritual boredom is associated with over- and underchallenge, lack of value, and reduced motivation.
Commun Psychol
March 2025
Department of Psychology, University of Essex, Essex, UK.
The emotion of boredom has attracted considerable research interest. However, boredom experienced in spiritual contexts (i.e.
View Article and Find Full Text PDFThe impact of meditation on sustained attention in nonclinical population: An extensive review.
J Ayurveda Integr Med
March 2025
Department of Yoga Studies, School of Medicine and Public Health, Central University of Kerala, Tejaswini Hills, Periya PO, Kasaragod Dist., Kerala, 671320, India. Electronic address:
Background: Meditation, encompassing focussed attention (FA) and open monitoring (OM) approaches, is recognised for its potential to enhance cognitive functions. Sustained attention, a critical component of attentional processes, influences cognitive capacity and is linked to meditation benefits. However, a robust and extensive review analysis needs to address the specific relationship between meditation and sustained attention in nonclinical populations.
View Article and Find Full Text PDFA Scoping Review on the Efficacy/Effectiveness and Utilization of Complementary and Integrative Health for Pain in the Military Health System.
J Integr Complement Med
March 2025
Defense and Veterans Center for Integrative Pain Management, Department of Anesthesiology, Uniformed Services University, Bethesda, MD, USA.
This scoping review evaluated the efficacy/effectiveness and utilization of complementary and integrative health (CIH) therapies for pain management within the Military Health System (MHS). Specifically, it aimed to assess evidence-based modalities such as acupuncture, biofeedback, hypnosis, massage therapy, meditation, guided imagery, Tai Chi/Qi Gong, and yoga, which are part of the Veterans Administration's (VA) Whole Health program. The goal was to determine their effectiveness in military service members and understand their utilization in the MHS, as well as explore CIH research in the MHS to identify gaps.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!