Fibre traces recovered from the respiratory tract have the potential to be informative in cases of suspected smothering. In order to interpret such findings, it is important to understand the background population of fibres in respiratory tract such that the probabilities of adventitious recovery of such fibres can be assigned. This study builds upon previous studies by first testing various recovery methods on both living participants and cadavers. Once the most suitable recovery methods were identified, background sampling of fibres was carried out on living volunteers in the nostrils (using swabs) and oral cavities (using a rinse and filter method), as well as on cadavers in the nasal cavity and trachea (using AccuTrans® mould). A population study was carried out on these fibres to understand the occurrences of each generic class and colour of fibre groups and their lengths in these regions. A deeper analysis of non-differentiated fibre groups was also carried out to assess the group sizes expected in the background population. Ultimately, the results of the population study align closely in terms of frequencies with the general background population of other surfaces. Fibre group sizes were also generally small, with the largest group being three fibres.
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http://dx.doi.org/10.1016/j.forsciint.2025.112410 | DOI Listing |
Biosaf Health
December 2024
Vanke School of Public Health, Tsinghua University, Beijing 100084, China.
In the last century, global pandemics have been primarily driven by respiratory infections, which consistently rank among the top 20 causes of death worldwide. The coronavirus disease 2019 (COVID-19) pandemic has underscored the intricate nature of managing multiple health crises simultaneously. In recent years, climate change has emerged as a major biosafety and population health challenge.
View Article and Find Full Text PDFInt J Chron Obstruct Pulmon Dis
March 2025
Department of Respiratory Medicine, The second Affiliated Hospital, Hainan Medical University, Haikou, 570100, People's Republic of China.
Background: Chronic obstructive pulmonary disease (COPD) has emerged as a very consequential issue threatening human life and health; therefore, research on its pathogenesis is urgently needed. A prior investigation discovered a significant elevation in the phosphoglycerate mutase 5 (PGAM5) expression in the lung tissue of COPD smoking patients. This rise in expression is closely associated with COPD severity.
View Article and Find Full Text PDFInt J Chron Obstruct Pulmon Dis
March 2025
Real World Data Analytics, Japan Development, GSK, Tokyo, Japan.
Purpose: Following the relatively recent introduction of single-inhaler triple therapies in Japan, this study compared the effectiveness of switching from multiple-inhaler triple therapy (MITT) to once-daily fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) by investigating COPD exacerbations and adherence among patients with chronic obstructive pulmonary disease (COPD) in Japan.
Methods: This retrospective, pre-post cohort study using the Medical Data Vision Co. Ltd database identified patients with ≥1 inpatient diagnosis and/or ≥2 outpatient diagnoses of COPD at age ≥40 years prior to the index date (first/earliest date of single-inhaler FF/UMEC/VI initiation from May 1, 2019-February 28, 2022, following a switch from MITT).
Int J Chron Obstruct Pulmon Dis
March 2025
Department of General Medical, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, People's Republic of China.
Purpose: The miR-125a-5p has been reported influence the development of lung cancer, however, the link between it and chronic obstructive pulmonary disease (COPD) is still not well understood. Hence, this study was designed to investigate the molecular pathway by which miR-125a-5p related biomarkers were involved in COPD.
Patients And Methods: The differentially expressed genes (DEGs) and module genes related to COPD in GSE100153 were screened out by differential analysis and weighted gene co-expression network analysis, respectively.
Front Public Health
March 2025
National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Background: Understanding health system delay (HSD) in pulmonary tuberculosis (PTB) diagnosis aids in tailoring interventions for case detection and curbing transmission. However, recent nationwide studies on HSD in PTB diagnosis have been scarce. This study assesses HSD and its risk factors in China, taking into account the impact of the COVID-19 epidemic.
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