Buruli ulcer (BU) is a rare, neglected tropical disease caused by Mycobacterium ulcerans that can lead to severe skin ulcers. To determine the epidemiology of BU in Victoria, Australia, during 2017-2022 we analyzed surveillance data. A total of 1,751 cases of BU were notified; 968 (55%) patients were male and 781 (45%) female (2 were missing sex data), and 984 (56%) resided in established BU-endemic areas, although an increasing number were in new BU-endemic areas. Most cases (83%, 1,301) were classified as category I. Multivariate modeling demonstrated that factors for severe BU included being male, being older, and living in a new BU-endemic or non-BU-endemic area. A relatively shorter interval between first visit to a clinician and receipt of diagnosis was protective against severe disease. The expansion of BU-endemic areas throughout Victoria remains a public health concern and calls for targeted action, particularly for patients and clinicians in new BU-endemic areas.
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Buruli ulcer (BU) is a rare, neglected tropical disease caused by Mycobacterium ulcerans that can lead to severe skin ulcers. To determine the epidemiology of BU in Victoria, Australia, during 2017-2022 we analyzed surveillance data. A total of 1,751 cases of BU were notified; 968 (55%) patients were male and 781 (45%) female (2 were missing sex data), and 984 (56%) resided in established BU-endemic areas, although an increasing number were in new BU-endemic areas.
View Article and Find Full Text PDFBuruli ulcer surveillance in south-eastern Australian possums: Infection status, lesion mapping and internal distribution of Mycobacterium ulcerans.
PLoS Negl Trop Dis
November 2024
Melbourne Veterinary School, Department of Veterinary Biosciences, Faculty of Science, The University of Melbourne, Werribee, Victoria, Australia.
Article Synopsis
- Buruli ulcer (BU) is a neglected tropical disease caused by the bacterium Mycobacterium ulcerans, primarily affecting skin and subcutaneous tissue, with transmission dynamics varying by geographic area, particularly in endemic regions like Victoria, Australia.
- In a study conducted in Melbourne and Geelong, researchers conducted necropsies and surveillance on possums, revealing that 77% of the 26 examined possums were common ringtails, with 9 showing cutaneous ulcers and 73% testing positive for M. ulcerans DNA, indicating a significant reservoir in these animals.
- The findings suggest that possums may contract BU through bites from infected mosquitoes, environmental sources, or wounds, highlighting the need for a One Health approach to
To examine protective and risk factors for Buruli ulcer (BU), we conducted a case-control study of 245 adult BU cases and 481 postcode-matched controls across BU-endemic areas of Victoria, Australia. We calculated age- and sex-adjusted odds ratios for socio-environmental, host, and behavioral factors associated with BU by using conditional logistic regression. Odds of BU were >2-fold for persons with diabetes mellitus and persons working outdoors who had soil contact in BU-endemic areas (compared with indoor work) but were lower among persons who had bacillus Calmette-Guérin vaccinations.
View Article and Find Full Text PDFUtilising community volunteers can increase the detection and referral of Buruli ulcer cases in endemic communities in Southeast, Nigeria.
Trop Dis Travel Med Vaccines
November 2022
Department of Family Medicine, Alex Ekwueme Federal University Teaching Hospital Abakaliki, Abakalik, Ebonyi State, Nigeria.
Background: Buruli ulcer (BU) is a debilitating neglected tropical disease which causes disability and mostly affects inhabitants in impoverished settings where access to medical care is challenging. This study aims to determine the effect of training community members as volunteers for or in the detection and referral of people who have Buruli ulcer to the hospital.
Methods: The following study is a before and after study in the BU-endemic Local Government Areas (LGA) of Ebonyi State.
Buruli ulcer (BU) is a destructive soft-tissue infection caused by the environmental pathogen Mycobacterium ulcerans. In response to rising BU notifications in the state of Victoria, Australia, we reviewed all cases that occurred during 2011-2016 to precisely map the time and likely place of M. ulcerans acquisition.
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