This review provides insight into the different types of laser-based and energy-based therapies used in the treatment of hidradenitis suppurativa. It further explores the differences among some of the more commonly utilized laser modalities and the indications for their use (ie, scar treatment and hair follicle destruction).
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From Castaways to Discoveries: Unveiling Treasures in Skin RNAseq Using a Novel Multidimensional Data Processing Workflow Including Infection-Host Dynamics.
Physiol Genomics
March 2025
College of Human Medicine, Michigan State University, Grand Rapids, MI 49503 USA.
Defining physiology and methods to measure biological mechanisms is essential. Extensive datasets such as RNA sequencing are used with little analysis of the knowledge gained from the various methodologies. Within this work, we have processed publicly available NCBI RNAseq datasets using a combination of bioinformatics tools for the largest physiological organ, the skin.
View Article and Find Full Text PDFCausal relationship and potential common pathogenic mechanisms between hidradenitis suppurativa and related cancer.
Discov Oncol
March 2025
Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Background: Hidradenitis suppurativa (HS) is a chronic, inflammatory and common skin disease. Observation studies have reported the association between HS and cancers, however no studies reported whether a causal relationship exists between HS and cancers. This study aimed to explore the causal relationship between HS and differential subtypes of cancers by conducting a bidirectional Mendelian randomization (MR) analysis.
View Article and Find Full Text PDFCumulative life course impairment: Evidence for hidradenitis suppurativa.
J Eur Acad Dermatol Venereol
March 2025
Clinical Laboratory for Epidemiology and Applied Research in Skin (CLEARS), Department of Dermatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Hidradenitis suppurativa (HS) adversely affects quality of life, education, work, relationships and mental health. The debilitating effects of HS can compound over a patient's lifetime and have lasting repercussions. The cumulative life course impairment (CLCI) model analyses the disease factors that could affect the life course trajectory of a patient, including effects on major life decisions and opportunities, such as relationships, career path, education and starting a family.
View Article and Find Full Text PDFEfficacy and safety of biologics for hidradenitis suppurativa: A network meta-analysis of phase III trials.
J Eur Acad Dermatol Venereol
March 2025
Department of Dermatology and Allergy, University Hospital, LMU, Munich, Germany.
Background: Phase III clinical trials are designed to evaluate the therapeutic effect of drugs and their superiority over other treatment methods, but biologics for hidradenitis suppurativa (HS) have not been compared head-to-head in phase III studies.
Objective: To evaluate the relative efficacy and safety of biologics for HS in a network meta-analysis including available data from phase III trials.
Methods: MEDLINE and Embase were searched for phase III trials investigating the efficacy and/or safety of at least one biologic for moderate-to-severe HS.
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