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Response to: Nociplastic pain in rheumatology.
Ann Rheum Dis
March 2025
Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA. Electronic address:
Purpose: If the pain persists for a long time in the treatment of plantar fasciitis (PF) or if there is no response to treatment, central sensitization (CS) may develop and the pain may transform into nociplastic pain (NP). This study aimed to evaluate the frequency of CS and NP in patients with PF.
Methods: This cross-sectional study was undertaken between November 2023 and March 2024.
Pharmacological interactions of sulforaphane and gabapentin in a murine fibromyalgia-like pain model.
Biomed Pharmacother
March 2025
Laboratorio de dolor y analgesia, Centro de Investigación y de Estudios Avanzados-Sede Sur, Calz. De los Tenorios. Tlalpan, Ciudad de México 14330, Mexico. Electronic address:
Therapeutic management of a chronic painful syndrome such as fibromyalgia (FM) lacks effective and safe single or combined analgesics. Current medications such as gabapentin (GPB) or pregabalin are moderately effective but in the presence of several adverse effects. Natural products derived from cruciferous vegetables such as sulforaphane (SFN) produce neuroprotective effects due to their potent antioxidant and anti-inflammatory properties.
View Article and Find Full Text PDFImpact of botulinum toxin type A on ocular pain with neuropathic features.
Ocul Surf
February 2025
Surgical and Research Services, Miami Veterans Administration Medical Center, 1201 NW 16th St, Miami, FL, 33125, USA; Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA. Electronic address:
Purpose: To investigate the impact of botulinum toxin type A (BoNT-A) on neuropathic/nociplastic ocular pain (NOP) and identify predictors of patient outcomes.
Methods: A retrospective study of individuals with NOP symptoms (light sensitivity, wind/air sensitivity, persistent pain despite dry eye treatment) who received ≥1 BoNT-A injection. Primary outcome measures included if (responders vs.
Sex-Specific Sensory Profiles Discriminate Between Sensitization at Twelve Weeks in Patients with Acute Low Back Pain: A Retrospective Study.
J Clin Med
January 2025
Experimental Anatomy Research Group, Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
Low back pain (LBP) is the leading cause of disability worldwide, resulting in enormous socio-economic and personal consequences. Sensory profiles during the acute back pain stage will predict central sensitization symptoms in the chronic pain stage, as central sensitization is the main mechanism behind nociplastic pain and pain chronicity. Therefore, our objective was to establish overall and sex-specific sensory profile cut-off points that distinguish symptoms of central sensitization at 12 weeks, using a retrospective prognostic cohort study design.
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