Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/S0140-6736(25)00335-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Heme metabolism mediates RANKL-induced osteoclastogenesis via mitochondrial oxidative phosphorylation.
J Bone Miner Res
March 2025
School of Biomedical Sciences, University of Western Australia, Perth, Western Australia, Australia.
Bone undergoes life-long remodelling, in which disorders of bone remodelling could occur in many pathological conditions including osteoporosis. Understanding the cellular metabolism of osteoclasts is key to developing new treatments for osteoporosis, a disease that affects over 200 million women worldwide per annum. We found that human osteoclast differentiation from peripheral blood mononuclear cells (PBMCs) derived from 8 female patients is featured with a distinct gene expression profile of mitochondrial biogenesis.
View Article and Find Full Text PDFSchisandrin B targets CDK4/6 to suppress proliferation and enhance radiosensitivity in nasopharyngeal carcinoma by inducing cell cycle arrest.
Sci Rep
March 2025
The Key Laboratory of Biomarker High Throughput Screening and Target Translation of Breast and Gastrointestinal Tumor, Affiliated Zhongshan Hospital of Dalian University, No.6 Jiefang Street, Zhongshan District, Dalian, 116001, Liaoning, China.
Nasopharyngeal carcinoma (NPC) is notably prevalent in East and Southeast Asia, where despite advancements in radiotherapy leading to high control rates, challenges like radioresistance and collateral tissue damage remain significant. While Schisandrin B (SchB) has been demonstrated antitumor effects in various tumors, its efficacy in NPC remains unexplored. In this study, we explored the antitumor potential of Sch B on NPC, particularly its effects on cell proliferation and radiosensitivity.
View Article and Find Full Text PDFRelaxation of Photoexcited Electron-Hole Pairs at Si(111) Surfaces with Adsorbed Ag Monolayered Clusters of Increasing Size.
J Phys Chem Lett
March 2025
Department of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58102, United States.
The efficiency of silicon solar cells is affected by the light absorption and recombination losses of photoexcited charge carries. One possible way to improve the efficiency is through the deposition of transition metal nanoparticles on Si surfaces. Here, we first carry out density functional theory (DFT) calculations to obtain electronic structures for Ag ( = 1-7) monolayered clusters adsorbed on Si(111)/H surfaces.
View Article and Find Full Text PDFNormalization of the percentage of signal recovery derived from dynamic susceptibility contrast perfusion MRI in brain tumors.
Neuroradiology
March 2025
UCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision and Imaging Biomarkers, University of California Los Angeles, Los Angeles, CA, USA.
The universalizability of the metric percentage of signal recovery (PSR) derived from dynamic susceptibility contrast (DSC) perfusion MRI is limited by its dependency of acquisition parameters. In this technical assessment, we tested different reference tissues for PSR normalization and found the normal-appearing white matter (NAWM) to have the least inter-patient variability when using a fixed PSR-optimized protocol. A logarithmic normalization using NAWM improved the consistency of PSR values when a cohort of brain tumor patients was analyzed by synthetically changing acquisition parameters (while keeping the protocol uniform within the cohort).
View Article and Find Full Text PDFPixel level deep reinforcement learning for accurate and robust medical image segmentation.
Sci Rep
March 2025
Institute of Logic and Computation, Vienna University of Technology, Vienna, Austria.
Existing deep learning methods have achieved significant success in medical image segmentation. However, this success largely relies on stacking advanced modules and architectures, which has created a path dependency. This path dependency is unsustainable, as it leads to increasingly larger model parameters and higher deployment costs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!