Comput Biol Chem
Computer Engineering Department, College of Computer and Information Sciences, King Saud University, Riyadh, Saudi Arabia.
Published: February 2025
In this study, we present a novel intelligent computing framework based on unsupervised random projection neural networks for analyzing the within-host transmission dynamics of the Chikungunya virus with an adaptive immune response. In addition to the fundamental analysis of the model, we perform comprehensive simulations under varying initial conditions to explore the dynamics in both the virus-free and endemic states. The proposed method is compared with existing numerical techniques in terms of absolute errors for different cases, considering different suitable initial values of the state variables. Numerical simulations demonstrated the effectiveness of the stochastic neural network, achieving minimal residual errors in the least amount of time compared to conventional methods, thereby validating the accuracy and robustness of the proposed approach. Moreover, these results demonstrate that a random projection neural networks approach is adept at managing complex dynamics, enhancing our comprehension of disease behavior. Furthermore, this study emphasizes the adaptability and reliability of machine learning techniques in analyzing and predicting epidemiological dynamics, as well as in transmission modeling.
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http://dx.doi.org/10.1016/j.compbiolchem.2025.108380 | DOI Listing |
Neuroscientist
March 2025
Cortical Labs, Melbourne, Australia.
Harnessing intelligence from brain cells in vitro requires a multidisciplinary approach integrating wetware, hardware, and software. Wetware comprises the in vitro brain cells themselves, where differentiation from induced pluripotent stem cells offers ethical scalability; hardware typically involves a life support system and a setup to record the activity from and deliver stimulation to the brain cells; and software is required to control the hardware and process the signals coming from and going to the brain cells. This review provides a broad summary of the foundational technologies underpinning these components, along with outlining the importance of technology integration.
View Article and Find Full Text PDFBiosaf Health
December 2024
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Viral infectious clones (ICs) serve as robust platforms for studying viral biology and screening antiviral agents using reverse genetics. However, the molecular profiles and complex limitations of human coronaviruses (HCoVs) pose a challenge to ICs development. In this study, we report a novel platform to develop the ICs for HCoV-OC43-VR1558 using a one-step assembly method in yeast by transformation-associated recombination (TAR) technology.
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March 2025
School of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Sydney, NSW 2006, Australia.
The landscape of artificial intelligence (AI) research is witnessing a transformative shift with the emergence of the Kolmogorov-Arnold network (KAN), presenting a novel architectural paradigm aimed to redefine the structural foundations of AI models, which are based on multilayer perceptron (MLP). Through rigorous experimentation and evaluation, we introduce the KAN-electroencephalogram (EEG) model, a tailored design for efficient seizure detection. Our proposed network is tested and successfully generalized on three different datasets, one from the USA, one from Europe, and one from Oceania, recorded with different front-end hardware.
View Article and Find Full Text PDFResearch (Wash D C)
March 2025
The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121012, China.
The metaverse enables immersive virtual healthcare environments, presenting opportunities for enhanced care delivery. A key challenge lies in effectively combining multimodal healthcare data and generative artificial intelligence abilities within metaverse-based healthcare applications, which is a problem that needs to be addressed. This paper proposes a novel multimodal learning framework for metaverse healthcare, MMLMH, based on collaborative intra- and intersample representation and adaptive fusion.
View Article and Find Full Text PDFMaterials (Basel)
February 2025
School of Mechanical and Automotive Engineering, Xiamen University of Technology, Xiamen 361024, China.
As internal combustion engines (ICEs) develop towards higher explosion pressures and lower weights, their structures need to be more compact; thus, the wall thickness of their cylinder liners is reducing. However, intense vibrations in the cylinder liner can lead to coolant cavitation and, in severe cases, penetration of the liner, posing a significant reliability issue for ICEs. Therefore, research on cylinder liner cavitation has attracted increasing interest.
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