In this study, a new background discrimination method using SVM with gaussian kernel in low-level H liquid scintillation measurement is developed. Dimensionality reduction techniques were employed to process the full waveform data of each event following time discrimination. The reduced-dimensional data were then used to construct the classification model. To ensure a fair comparison with traditional method, the advantages of offline processing were employed to systematically traverse all possible parameter configurations within reasonable ranges, enabling the determination of the optimal parameters. In machine learning-based background event discrimination, the high-quality labeled datasets are obtained through long-term measurements of blank samples and short-term measurements of medium-activity H samples. Additionally, a series of low-activity H samples with activity levels of approximately 1 Bq, 3 Bq, and 5 Bq were prepared through quantitative dilution. The results demonstrate that the proposed method achieves a significant improvement in discrimination capability compared to traditional method. It effectively minimizes background levels across the entire energy range while preserving detection efficiency, significantly enhancing the measurement capability for low-activity H samples.
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http://dx.doi.org/10.1016/j.apradiso.2025.111754 | DOI Listing |
Arch Med Res
March 2025
Chair and Department of Medical Chemistry and Laboratory Medicine, Poznan University of Medical Sciences, Poznań, Poland; Hospital Pharmacy, Greater Poland Cancer Center, Poznań, Poland.
Background: The monocyte CCR2-CCL2 axis appears to play a crucial role in the generation of tumor-associated macrophages (TAMs), which subsequently promotes tumor metastasis and resistance to therapy.
Aims: Our study assessed the monocyte CCR2-CCL2 axis in triple-negative breast cancer (TNBC) and its ability to predict tumor response to neoadjuvant chemotherapy (NAC).
Methods: The study included 42 female patients diagnosed with TNBC and eligible for NAC.
Clinics (Sao Paulo)
March 2025
Evidence-based Medicine and Clinical Epidemiology Center, Army Medical University (Third Military Medical University), PR China. Electronic address:
Background: This study aimed to assess the predictive value of 7 routinely available inflammation biomarkers for stroke and all-cause mortality in 229 non-valvular AF patients.
Methods And Results: C-reactive protein, Albumin (ALB), d-dimer, fibrinogen, the number of platelets, lymphocytes, monocyte and neutrophils were measured. The Multivariable Cox proportional hazard model was used to assess the predictive value of the inflammation biomarkers for stroke and all-cause mortality, the c-statistic, Net Reclassification Improvement (NRI), and Integrated Discrimination Improvement (IDI) were calculated.
J Cutan Med Surg
March 2025
Department of Dermatology, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey.
Background: Early melanomas, dysplastic melanocytic nevi, and melanocytic tumours of uncertain malignant potential (MELTUMPs) reveal similar clinic and dermoscopic findings leading to underdiagnosis of malign lesions or unnecessary excision of benign ones. High-grade dysplastic nevi and MELTUMPs in the intermediate category should be recognized and completely excised.
Objectives: We evaluated the diagnostic performance of pattern analysis, ABCD rule, colour, architecture, symmetry, and homogeneity algorithm, melanoma-specific structures and asymmetry of dermoscopic features in distinguishing early melanomas, high-grade dysplastic nevi, and MELTUMPs from low-grade dysplastic nevi.
Front Sociol
February 2025
Faculty of Social and Educational Sciences, University of Passau, Passau, Germany.
This article argues that there is a close relationship between individuals' understandings of specific incidents of racism, their ideas of how racism operates, and their (repertoires of) responses to such incidents. The argument is based on a qualitative interview study with 21 highly educated Black Germans with at least one parent born outside Germany, and draws on both the extant literature on responses to experiences of ethnoracial exclusion and research into how people make sense of such experiences. The analysis specifically explores two contrasting types of interviewees: Type 1 felt that they were constantly and potentially always affected by racism and had a broad knowledge of racism.
View Article and Find Full Text PDFInt J Gen Med
March 2025
Department of Cardiology, Tianjin Chest Hospital, Tianjin, People's Republic of China.
Background: Severe in-stent restenosis (ISR) following the implantation of drug-eluting stent (DES) can lead to recurrent angina pectoris or even acute myocardial infarction, thereby necessitating target lesion revascularization (TLR). Prior studies have confirmed the correlation between the monocyte to high-density lipoprotein cholesterol ratio (MHR) and ISR after DES implantation. The potential of MHR to predict TLR following DES implantation remains an area of ongoing research and may have significant clinical implications.
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