Purpose: The frequency and popularity of immediate sequential bilateral cataract surgery (ISBCS) is increasing. We discuss the course of rehabilitation for a patient who underwent ISBCS and developed toxic anterior segment syndrome (TASS) in both eyes.
Methods: This study is a case report.
Results: The patient was a 42-year-old woman with no remarkable past medical history who underwent ISBCS at another hospital in 2023. Intraoperatively, mitomycin C (MMC) was inadvertently instilled into the anterior chamber of both eyes at the conclusion of surgery instead of carbachol (Miostat®). The next day, the patient noticed vision loss, and an ophthalmological examination revealed corneal edema in both eyes. She was referred to our hospital with the diagnosis of bilateral TASS. Although the left eye began to improve after a week of medical treatment, the right eye finally required Descemet's membrane endothelial keratoplasty. At the 2-month postoperative visit, uncorrected distance visual acuity was 0.7 bilaterally, and both corneas were clear on slit lamp biomicroscopy.
Conclusion: Although ISBCS provides convenience in many areas, we believe that it should be performed only for particular indications and conditions, because it may lead to severe problems such as bilateral blindness.
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http://dx.doi.org/10.1016/j.jfo.2025.104458 | DOI Listing |
Unlabelled: Familial mutations in myocilin cause vision loss in glaucoma due to misfolding and a toxic gain of function in a senescent cell type in the anterior eye. Here we characterize the cellular behavior and structure of the myocilin (myocilin ) mutant, of uncertain pathogenicity. Our characterization of A427T demonstrates that even mutations that minimally perturb myocilin structure and stability can present challenges for protein quality control clearance pathways.
View Article and Find Full Text PDFSci Rep
March 2025
Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, MA, Boston, United States.
Primary open angle glaucoma (POAG) and infantile aphakic glaucoma (IAG) are significant contributors of vision loss in adults and infants respectively. Both indications are associated with fibrosis of the trabecular meshwork (TM) that attenuates aqueous humor outflow, elevated intraocular pressure (IOP) and retinal ganglion cell (RGC) death. Transforming growth factor β2 (TGFβ2) is implicated in epithelial to mesenchymal transition (EMT) in both POAG and IAG.
View Article and Find Full Text PDFJACC CardioOncol
February 2025
Division of Cardiology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address:
Background: Radiation therapy (RT) improves breast cancer outcomes, but cardiac morbidity remains a concern.
Objectives: This study sought to evaluate changes in cardiac function after RT and the relationship between cardiac dose metrics and echocardiography-derived measures of function.
Methods: In a longitudinal cohort study of women with breast cancer, radiation cardiac dose metrics and core lab quantitated echocardiographic measures of cardiac function were evaluated.
Transl Neurodegener
March 2025
Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Background: Intraneuronal accumulation of hyperphosphorylated tau is a hallmark of Alzheimer's disease (AD). Given the significant correlation between tau pathology and memory loss in AD patients, identifying vulnerable brain regions, particularly susceptible neuron types in these regions, will advance our understanding of AD onset and shed light on therapeutic strategies to manage its progression.
Methods: Immunofluorescent staining was employed to identify the brain regions and neuron types vulnerable to tau pathology in AD.
Rev Cardiovasc Med
February 2025
Department of Radiation Oncology, School of Medicine, Kocaeli University, 41001 Kocaeli, Turkey.
Background: One of the most significant long-term toxicities of breast cancer radiotherapy is major adverse cardiac events (MACE). In current radiotherapy practice, the mean heart dose is the most commonly used parameter. The aim of our study was to reduce the doses of organs at risk (OAR) in the left anterior descending artery (LAD) and left ventricle (LV) by including the LAD and LV in planning radiotherapy while maintaining adequate dose coverage for patients with left-sided breast cancer.
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