Facing the 2035 nationally determined contributions and carbon neutral target, the mitigation potential and cost of fluorinated gases (F-gases), fast-growing greenhouse gases, need to be evaluated. Applying the established DECAF model, this study assessed China's F-gas mitigation potential, as well as its climate and economic impacts. Over 2021-2060, territorial cumulative GWP-weighted F-gas abatement of 42∼50 gigatonnes CO-eq (62%-74% reduction) could be achieved in China at the cost of 30∼44 USD/t CO-eq, with remaining emissions of 143∼390 Mt CO-eq yr in 2060. Of these, the product use sector with significant banks dominates 63%-67% of the total abatement at the cost below 16 USD/t CO-eq. End-of-life management (like recovery) is recommended as a cost-effective measure with high emission reduction potential, while a postponed schedule for F-gas abatement in the electronics industry is proposed due to its high abatement costs. Accelerating HFC reductions and extending abatement actions to cover all F-gases in China could avoid a temperature increase of 0.11-0.18 °C by 2100, rising to 0.23-0.43 °C if scaled globally.
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http://dx.doi.org/10.1016/j.jenvman.2025.124715 | DOI Listing |
Biomol Biomed
March 2025
Department of Clinical Nutrition, Chongqing Jiangjin District Central Hospital/Chongqing University Affiliated Jiangjin Hospital, Chongqing, China.
Cancer therapy-related cardiac dysfunction (CTRCD) is a major concern for patients undergoing cardiotoxic cancer treatments. Sodium-glucose co-transporter-2 (SGLT2) inhibitors have shown cardioprotective effects in both diabetic and non-diabetic populations. However, their impact on CTRCD risk remains uncertain.
View Article and Find Full Text PDFMol Pharm
March 2025
Merck & Co., Inc., Rahway, New Jersey 07065, United States.
This is the fourth paper in a series describing an inhalation biopharmaceutics classification system (iBCS), an initiative supported by the Product Quality Research Institute. The paper examines the application of the inhalation Biopharmaceutics Classification System (iBCS) through the drug discovery, development, and postapproval phases for orally inhaled drug products (OIDP) and for the development of generic OIDPs. We consider the implication of the iBCS class in terms of product performance and identify the practical gaps that must be filled to enable the classification system to be adopted into day-to-day practice.
View Article and Find Full Text PDFFASEB J
March 2025
Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.
Glaucoma, a leading cause of irreversible blindness, is characterized by the progressive loss of retinal ganglion cells (RGCs) and optic nerve damage, often associated with elevated intraocular pressure (IOP). Retinoid X receptors (RXRs) are ligand-activated transcription factors crucial for neuroprotection, as they regulate gene expression to promote neuronal survival via several biochemical networks and reduce neuroinflammation. This study investigated the therapeutic potential of 9-cis-13,14-dihydroretinoic acid (9CDHRA), an endogenous retinoid RXR agonist, in mitigating RGC degeneration in a high-IOP-induced experimental model of glaucoma.
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March 2025
State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, P. R. China.
Copper exposure poses potential detrimental effects on both public and ecosystem health. Spermidine, an antioxidant, has shown promise in reducing oxidative stress and inflammation within the liver. However, its specific role in mitigating copper-induced hepatic cuproptosis and disturbances in copper metabolism remains unexplored.
View Article and Find Full Text PDFAdv Mater
March 2025
Pritzker School of Molecular Engineering, The University of Chicago, 5801 South Ellis Avenue, Chicago, IL, 60637, USA.
Rechargeable aqueous batteries based on metallic anodes hold tremendous potential of high energy density enabled by the combination of relatively low working potential and large capacity while retaining the intrinsic safety nature and economical value of aqueous systems; However, the realization of these promised advantages relies on the identification of an ideal metal anode chemistry with all these merits. In this review, the emerging Sn metal anode chemistry is examined as such an anode candidate in both acidic and alkaline media, where the inertness of Sn toward hydrogen evolution, flat low voltage profile, and low polarization make it a unique metal anode for aqueous batteries. From a panoramic viewpoint, the key challenges and detrimental issues of Sn metal batteries are discussed, including dead Sn formation, self-discharge, and electrolyte degradation, as well as strategies for mitigating these issues by constructing robust Sn anodes.
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