The 4Ms Framework is the foundation of the Age-Friendly Health System (AFHS) movement. While the framework is based on standalone evidence for each M, there is limited evidence about the impact on outcomes when practiced as a set. A composite measure capturing adherence to the many care processes that comprise the 4Ms is a necessary but complex component of closing the evidence gap. We offer a navigation guide that addresses key considerations for developing a hospital-based composite measure of 4Ms care. The Institute for Healthcare Improvement operationalizes the 4Ms Framework as a minimum set of Assessment and Act On care processes. In developing a composite measure of inpatient 4Ms adherence, we offer a 4 step framework with associated discussion of considerations related to composite measure type (eg, continuous, dichotomous), and synchrony within and across the Ms containing these care processes. Using real-world electronic health record data capturing care process adherence in the 4Ms implementation at a large academic hospital, we illustrate the considerations, and report the implications for sample size and composite measure scoring. We also present our selected composite measure-a dichotomous measure delineating 4Ms care when all encounter-level processes (those needing to be done only once during the hospital encounter) are followed and all day- and shift-level processes are followed for at least 50% of hospital days. While there is no single, standard approach to create a 4Ms composite at this early stage of the AFHS movement, as organizations develop their measure(s), our guide and the considerations we suggest should serve to inform this process and support progress toward meaningful measurement.
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http://dx.doi.org/10.1177/00469580251323135 | DOI Listing |
J Esthet Restor Dent
March 2025
University of Florida, College of Dentistry, Gainesville, Florida, USA.
Objectives: This in vitro study evaluated the effects of simulated toothbrushing on surface roughness, gloss, and color stability of milled and printed resin-based and lithium disilicate materials for permanent dental restorations.
Materials And Methods: Five materials were tested, including CAD/CAM prepolymerized resin blocks, a ceramic material, a resin composite and a newly FDA-cleared 3D-printed resin for permanent crowns. Specimens underwent a controlled brushing protocol simulating 5 years of brushing (50,000 cycles).
Nanoscale
March 2025
Key Laboratory of Applied Surface and Colloid Chemistry, Shaanxi Normal University, Ministry of Education, Xi'an, 710062, P. R. China.
Sodium nickel phosphate (NaNiPO, NNP) is an attractive cathode material for high performance supercapacitors due to its abundance of active sites for oxidation/reduction, highly stable framework structure, . However, its disadvantages of low electric conductivity, disturbances of its impure crystalline phase, and the numerous pores/gaps produced by agglomerated polycrystalline morphologies in this cathode often limit its electrochemical performance. Herein, single-crystalline NNP rod-like nanoparticles with high phase purity have been prepared by spontaneous combustion combined with subsequent solid-phase calcination.
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Iran J Pharm Res
November 2024
Department of Tissue Engineering and Applied Cell Sciences, Faculty of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Background: Invasive cervical cancer is recognized as the second most common malignancy in women after breast cancer.
Objectives: This study investigates, for the first time, the effect of gold nanoparticle-doped graphene oxide (GO) nanosheets on the human epithelial carcinoma (HeLa) cell line in the presence of heliox cold plasma.
Methods: Graphene oxide nanosheets were synthesized using the Hummer method and then doped with gold nanoparticles.
Heliyon
February 2025
Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and University and Hospital Trust (AOUI) of Verona, Italy.
A 55-year-old female patient affected by an EGFR mutant NSCLC with multiple lytic bone metastases and two prior pathological fractures, undergoing treatment with osimertinib and denosumab, participated in a 9-month physical exercise program. The exercise program was performed twice a week and consisted of aerobic and strength training. Aerobic training was composed of moderate-intensity continuous training for the first 3 months and then high-intensity interval training.
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