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Telomeric RNA quadruplexes as targets for cancer prevention: The therapeutic potential of agonodepsides.
J Genet Eng Biotechnol
March 2025
Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India. Electronic address:
Background: Cancer remains an awful challenge, despite years of targeting proteins to control its relentless growth and spread. Fungal metabolites, a treasure of natural chemicals, offer a glimmer of hope. Telomeres, the cellular "caps," are a focal point in cancer research.
View Article and Find Full Text PDFRecombinant production and characterization of six ene-reductases from Pencillium steckii.
Chembiochem
March 2025
University of Groningen, Molecular Enzymology group, Nijenborgh 4, 9747AG, Groningen, NETHERLANDS, KINGDOM OF THE.
Fungi, known for their adaptability, are valuable sources of enzymes, making them promising for biocatalyst discovery. This study explored Penicillium steckii, primarily recognized for secondary meta-bolite production, as a source of ene-reductases (ERs), which reduce α,β-unsaturated compounds. Eleven ER-encoding genes were iden-tified, and plasmids for Escherichia coli expression were generated.
View Article and Find Full Text PDFHOTAIR Participation in Glycolysis and Glutaminolysis Through Lactate and Glutamate Production in Colorectal Cancer.
Cells
March 2025
Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (UNAM), Tlalnepantla 54090, Mexico.
Metabolic reprogramming plays a crucial role in cancer biology and the mechanisms underlying its regulation represent a promising study area. In this regard, the discovery of non-coding RNAs opened a new regulatory landscape, which is in the early stages of investigation. Using a differential expression model of HOTAIR, we evaluated the expression level of metabolic enzymes, as well as the metabolites produced by glycolysis and glutaminolysis.
View Article and Find Full Text PDFAdvances in gut microbiota-related treatment strategies for managing colorectal cancer in humans.
Cancer Biol Med
March 2025
Hangzhou Institute of Medicine (HIM), Chinese Academy of Science, Hangzhou 310022, China.
Colorectal cancer (CRC) is a major contributor to global cancer-related mortality with increasing incidence rates in both developed and developing regions. Therefore, CRC presents a significant challenge to global health. The development of innovative tools for enhancing early CRC screening and diagnosis, along with novel treatments and therapies for improved management, remains an urgent necessity.
View Article and Find Full Text PDFMetabolic Activation of -Anethole Plays a Role in Hepatic Cytotoxicity in Mice.
J Agric Food Chem
March 2025
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.
-Anethole (1-methoxy-4-[1()-propenyl]benzene, tAT) is the main ingredient in the essential oil extracted from star anise fruits. The double bonds in the side chain of tAT are a type of alert structure that can be metabolized into epoxides possibly causing liver damage. This work investigated and identified the reactive metabolites of tAT that are chemically reactive to biothiols, such glutathione (GSH), -acetyl-l-cysteine (NAC), and cysteine residues of proteins.
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