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In this review, we outline key practical components of the nutritional management of critically-ill children in the context of the current peer reviewed literature and identify vital knowledge gaps for further investigation. Emerging areas of research are discussed, including skeletal muscle ultrasonography for measurement of skeletal muscle, and the potential future role of pre- and probiotics.
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http://dx.doi.org/10.1016/j.ccc.2024.11.003 | DOI Listing |
J Neurol
March 2025
Copenhagen Neuromuscular Center, Department of Neurology, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Background: Spinal muscular atrophy (SMA) is a motor neuron disease with loss of musculature, which is replaced by fat. Previous magnetic resonance imaging (MRI) studies have focused on imaging muscles either in lower or upper extremities, but whole-body MRI can provide additional information on the involvement pattern. This study examined whole-body muscle fat replacement and the relationship between muscle structure, function, and bulbar symptoms.
View Article and Find Full Text PDFMed Sci Monit
March 2025
Department of Health Education, Medical University of Lublin, Lublin, Poland.
BACKGROUND Pelvic floor dysfunction (PFD) significantly reduces quality of life. During horseback riding, the movement of the horse's back affects the tension of the pelvic floor muscles. This study aimed to compare reported symptoms of pelvic floor dysfunction in women with past, current, and no history of horse show jumping.
View Article and Find Full Text PDFCell Biochem Biophys
March 2025
Department of Medical Laboratory Science, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
The myosin regulatory light chain 2 (MLC2) is a crucial regulator of myosin activity. Its phosphorylation, mediated by various kinases, plays a vital role in maintaining normal physiological functions in skeletal muscle, myocardium, smooth muscle, and nonmuscle cells. Moreover, MLC2 has been implicated in the development of many cancers through its phosphorylation.
View Article and Find Full Text PDFSci Rep
March 2025
Ludwig Boltzmann Institute for Cardiovascular Research at the Center for Biomedical Research and Translational Surgery, Medical University of Vienna, 1090, Vienna, Austria.
Duchenne muscular dystrophy (DMD), a severe muscle disease caused by mutations in the gene encoding for the intracellular protein dystrophin, is associated with impaired cardiac function and arrhythmias. A causative factor for complications in the dystrophic heart is abnormal calcium (Ca) handling in ventricular cardiomyocytes, and restoration of normal Ca homeostasis has emerged as therapeutic strategy. Here, we used a rodent model of DMD, the dystrophin-deficient DMD rat, to test the following hypothesis: chronic administration of ivabradine (IVA), a drug clinically approved for the treatment of heart failure, improves Ca handling in dystrophic ventricular cardiomyocytes and thereby enhances contractile performance in the dystrophic heart.
View Article and Find Full Text PDFEur J Pharm Sci
March 2025
Department of Clinical Pharmacology, Faculty of Medicine, University of Helsinki, Finland; Individualized Drug Therapy Research Program, Faculty of Medicine, University of Helsinki, Finland; Department of Clinical Pharmacology, HUS Diagnostic Center, Helsinki University Hospital, Helsinki, Finland. Electronic address:
Statins are widely used in the treatment of hypercholesterolemia but also associated with muscle-related adverse effects. Multidrug resistance-associated protein (MRP) 1 and 5 are expressed in the skeletal muscle, where they may regulate intramuscular levels of their substrates. Here, we investigated the transport of various statins by MRP1 and MRP5 with the vesicular transport assay.
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