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A Comparative Study of the Effectiveness of Antibiotic-Steroid Ointment Wick V/S Antibiotic-Steroid Drops Soaked Gel Foam in Pain Management of Otitis Externa.
Indian J Otolaryngol Head Neck Surg
February 2025
Department of Otorhinolayrngology, Aarupadai Veedu Medical College and Hospital, Vinayaka Mission's Research Foundation (DU), Kirumampakkam, Puducherry India.
Otitis externa (OE), or swimmer's ear, is a common inflammatory condition affecting the external auditory canal, leading to symptoms such as ear pain, itching, and hearing impairment. It is caused by various pathogens, including Pseudomonas aeruginosa and Staphylococcus aureus. Treatment typically involves antibiotics, analgesics, and aural packing.
View Article and Find Full Text PDFTranscanal Endoscopic Repair of Cerebrospinal Fluid Otorrhea Secondary to Congenital Inner Ear Anomaly Using Topical Fluorescein.
Cureus
February 2025
Otolaryngology and Head and Neck Surgery, King Saud University, Riyadh, SAU.
An eight-year-old female, known to have sensorineural hearing loss due to inner ear anomalies, presented with a history of recurrent attacks of right acute otitis media complicated by bacterial meningitis. Temporal bone computed tomography showed right middle ear and mastoid effusion without bony dehiscence or erosion, with features of common cavity inner ear anomaly on the right side. Given the patient's inner ear malformation, cerebrospinal fluid (CSF) otorrhea was suspected.
View Article and Find Full Text PDFChildhood invasive pneumococcal disease and acute otitis media in Central Greece during 2005-2024 - A report at the doorstep of the new multivalent PCV era.
Vaccine
March 2025
Department of Pediatrics, School of Medicine, University of Thessaly, Larissa, Greece. Electronic address:
Background: In Greece, pneumococcal conjugate vaccines (PCVs) became sequentially available: 7-valent in October 2004, 10-valent in May 2009, 13-valent in June 2010 and 15-valent in March 2023; soon after availability all vaccines were incorporated in the National Ιmmunization Program except for PCV7 which was implemented in January 2006. Since July 2010, PCV13 has been the most commonly used PCV. Surveillance at a regional and a national level is a valuable tool to monitor the impact of PCVs.
View Article and Find Full Text PDFComparison of Streptococcus pneumoniae nasopharyngeal colonization, serotype-specific and protein-specific antibody and cytokine levels in young children prior to, during and post COVID-19 pandemic.
Vaccine
March 2025
Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester, NY, United States. Electronic address:
Background: We studied changes in pneumococcal epidemiology and immunology in young children at pre-COVID, during-COVID and post-COVID time-frames.
Methods: Pneumococci were cultured from nasopharynx and density semi-quantified at six healthy child visits, age 6-36 months, and during acute otitis media (AOM). Serum antibody levels were measured by ELISA.
Computer Integrated Dominant Epitopes Evoke Protective Immune Response Against Streptococcus pneumoniae.
Immunology
March 2025
ImmunoEngineering and Therapeutics Laboratory, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, India.
Streptococcus pneumoniae is a gram-positive bacterium responsible for various diseases like pneumonia, acute otitis media, sinusitis, meningitis and bacteraemia. These diseases cause a significant amount of morbidity and mortality. Although polysaccharide vaccines are available, the protection provided by these vaccines is serotype-dependent and not enough in sensitive populations like children and older people.
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