Comput Biol Med
National School of Computer Sciences, R377+FGR, Department of Information Systems and Decision Making, Campus Universitaire de Manouba, 2010, Manouba, Tunisia. Electronic address:
Published: February 2025
The mortality risk associated with breast cancer is experiencing an exponential rise, underscoring the critical importance of early detection. It is the primary cause of mortality among women under 50 and ranks as the second deadliest disease globally. Timely identification is crucial, as heightened public awareness and accurate diagnosis can significantly reduce mortality rates. Patients with a positive prognosis and timely diagnosis have a far greater chance of full recovery. A comprehensive study was conducted to develop a robust breast cancer detection system using Convolutional Neural Networks (CNNs). This study details the processes of data collection, preprocessing, model building, and performance evaluation. The Mini-DDSM dataset was utilized, which includes 1952 scanned film mammograms from a diverse population. Data preprocessing involved normalization, denoising, illumination correction, and augmentation techniques to enhance data quality and diversity. During the model-building stage, several CNN architectures were explored, including Basic CNN, FT-VGG19, FT-ResNet152, and FT-ResNet50. The FT-ResNet50 model, fine-tuned with transfer learning, emerged as the top performer, achieving an accuracy of 97.54%. The integrated system leverages the strengths of each model to deliver accurate and reliable results, significantly advancing early detection and treatment methods for breast cancer. The comparative analysis demonstrated that the developed models outperformed existing state-of-the-art models. By leveraging the capabilities of deep learning and meticulous design, the objective is to significantly advance early detection and treatment methods for breast cancer, leading to better patient outcomes and ultimately, saving lives.
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http://dx.doi.org/10.1016/j.compbiomed.2025.109858 | DOI Listing |
FASEB J
March 2025
Department of Oncology, The Central Hospital of Yongzhou, Yongzhou, Hunan, China.
The ribophorin family, including RPN1, has been associated with tumor progression, but its specific role in pan-cancer dynamics remains unclear. Using data from TCGA, GTEx, and Ualcan databases, we investigated the relationship of RPN1 with prognosis, genomic alterations, and epigenetic modifications across various cancers. Differential analysis revealed elevated RPN1 expression in multiple cancer types, indicating a potential prognostic value.
View Article and Find Full Text PDFCancer Med
March 2025
Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina, USA.
Introduction: Distress is common among cancer patients, especially those undergoing surgery. However, no study has systematically analyzed distress trends in this population. The purpose of this study was to systematically review perioperative rates of distress, as well as differences across cancer types, in cancer patients undergoing surgical intervention.
View Article and Find Full Text PDFFASEB J
March 2025
Cancer Center, The First Affiliated Hospital of Jilin University, Changchun, Jilin, China.
Breast cancer (BC) is one of the most common malignant tumors among women, accounting for 24.5% of all cancer cases and leading to 15.5% of cancer-related mortality.
View Article and Find Full Text PDFJ Biomol Struct Dyn
March 2025
Applied Organic Chemistry Department, National Research Center, Dokki, Egypt.
The discovery of novel, selective inhibitors targeting CDK2 and PIM1 kinases, which regulate cell survival, proliferation, and treatment resistance, is crucial for advancing cancer therapy. This study reports the design, synthesis, and biological evaluation of three novel pyrazolo[3,4-]pyridine derivatives (), confirmed spectral analyses. These compounds were assessed for anti-cancer activity against breast, colon, liver, and cervical cancers using the MTT assay.
View Article and Find Full Text PDFAdv Healthc Mater
March 2025
Department of Ultrasound, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, 361000, P. R. China.
The abnormal tumor mechanical microenvironment due to specific cancer-associated fibroblasts (CAFs) subset and low tumor immunogenicity caused by inefficient conversion of active chemotherapeutic agents are two key obstacles that impede patients with desmoplastic tumors from achieving stable and complete immune responses. Herein, it is demonstrated that FAP-αCAFs-induced stromal stiffness accelerated tumor progression by precluding cytotoxic T lymphocytes. Subsequently, a cascade-responsive nanoprodrug capable of re-educating FAP-αCAFs and amplifying tumor immunogenicity for potentiated cancer mechanoimmunotherapy is ingeniously designed.
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