Appl Physiol Nutr Metab
Faculty of Health Sciences University of Ottawa, Ottawa, Canada.
Published: February 2025
Recent evidence from modelling and laboratory-based studies showed that electric fans are ineffective at lowering core temperature in older adults at air temperatures of 36°C. However, their influence on self-reported environmental symptoms and mood-state during daylong use in hot indoor environments remains unclear. Eighteen older adults (8 females, median [interquartile range]; 72 [67-76 years]) completed three randomized 8-hour heat exposures (36°C, 45% relative humidity) with a fan generating air speeds of 0 (no fan, Control), 2, or 4 m/s at the front of the body positioned 1-m away. Participants were seated throughout, except for 4 x 10-min periods of simulated activities of daily living (stepping [~2.25 METs]). Core temperature, mean skin temperature, and heart rate areas under the curve (AUC, hours 0-8) were calculated to assess cumulative physiological strain. Total symptom scores (68-item environmental symptoms questionnaire) as well as total mood disturbance and energy index (40-item profile of mood states questionnaire) were evaluated at end-heating (adjusted for pre-exposure). Core temperature, mean skin temperatures, and heart rate AUCs were not different between conditions (all P≥0.087). Total symptom scores were 0.89-fold [0.81,0.97] lower with fan use (combined across speeds) compared to no fan (P=0.009). Energy index scores were 2.4 points [0.8,4.0] higher with fan use compared to no fan (P=0.004). However, mood disturbance was not significantly different between conditions (P=0.345). Our exploratory analysis show that fans can reduce self-reported symptoms and increase perceived energy levels in older adults in overheated indoor environments, despite no meaningful attenuation of physiological strain.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1139/apnm-2024-0461 | DOI Listing |
Am J Alzheimers Dis Other Demen
March 2025
Pathology Department, Chongqing UniversityCentral Hospital, Chongqing Emergency Medical Center, Chongqing, China.
White matter hyperintensity (WMH) is associated with cognitive impairment. In this study, 79 patients with WMH from hospital 1 were randomly divided into a training set (62 patients) and an internal validation set (17 patients). In addition, 29 WMH patients from hospital 2 were used as an external validation set.
View Article and Find Full Text PDFBr J Anaesth
March 2025
LIM 62 - Pain Center, Department of Neurology, São Paulo, Brazil; Center for Neuroplasticity and Pain (CNAP), Department of Health Science and Technology, University of Aalborg, Gistrup, Denmark. Electronic address:
Background: Despite affecting 2-4% of the population worldwide, fibromyalgia often remains refractory to treatment. Here we report the first international randomised double-blind, sham-controlled trial developed to assess the efficacy of repetitive transcranial magnetic stimulation (rTMS) as an add-on therapy for fibromyalgia.
Methods: Women aged ≥18 yr with fibromyalgia refractory to best available treatment were enrolled in Brazil, France, and Japan, and randomised to 10 Hz motor cortex (M1) rTMS, 3000 pulses day, or sham stimulation.
Sci Total Environ
March 2025
Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan; National Heart and Lung Institute, Imperial College London, London, UK; Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address:
Introduction: This systematic review examines how extreme temperatures impact Chronic Obstructive Pulmonary Disease (COPD) morbidity and mortality, focusing on identifying vulnerable subpopulations.
Methods: We conducted a systematic literature search from January 1, 2000, to November 6, 2024, across databases like PubMed, MEDLINE and EMBASE, Web of Science, and Scopus, focusing on observational studies that quantitatively defined extreme temperatures and their impacts on COPD morbidity and mortality. Out of 3140 records, 25 studies met the inclusion criteria.
Nutr Metab Cardiovasc Dis
February 2025
College of Public Health, University of South Florida, Tampa, FL, USA. Electronic address:
Background And Aim: We aimed to determine the optimal cut-off points for metabolic health indicators, including insulin resistance (IR), glucose, insulin, BMI, and waist circumference, in middle-aged nondiabetic people to predict future type 2 diabetes mellitus (T2DM).
Methods And Results: The data came from 12,543 Atherosclerosis Risk Communities Study participants, including 5758 men and 6785 women. They did not have diabetes at baseline and were followed for incident T2DM within 3, 6, and 9 years.
Expert Opin Drug Metab Toxicol
March 2025
Department of Pharmacy, Hospital Del Mar, Barcelona, Spain.
Introduction: New androgen receptor pathway inhibitors (ARPIs) are an essential part of the treatment strategy for patients with metastatic hormone-sensitive prostate cancer (mHSPC). Despite the good tolerability of ARPIs, after treatment is started, drug-drug interactions (DDIs) between these and other medications frequently taken by these patients may appear. DDIs may reduce the therapeutic effect of both and lead to increased adverse events.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!
© LitMetric 2025. All rights reserved.