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Relationship between intraperitoneal volume and intraperitoneal pressure during peritoneal dialysis-a pilot study in adult patients.
Physiol Rep
March 2025
Renal Research Institute, New York City, New York, USA.
Monitoring intraperitoneal pressure (IPP) offers valuable insights into changes of intraperitoneal volume (IPV) during peritoneal dialysis (PD). This study aims to investigate the relationship between IPV and IPP during a PD dwell. Thirteen patients were studied during a 2-h dwell using 2 L of dialysate containing 2.
View Article and Find Full Text PDFRetrobulbar/intraconal tube placement in patients with glaucoma: Ahmed FP-7 and tube extender case series with 1 year follow-up.
Front Ophthalmol (Lausanne)
February 2025
Department of Ophthalmology, Advanced Eyecare of New York, New York, NY, United States.
Purpose: The Ahmed FP-7 valve is useful in the management of refractory glaucoma. However, this can often have ocular hypertensive phase and subconjunctival fibrosis that can lead to increased medication use and failure. We report how retrobulbar and intraconal plate placement with tube extension can avoid the ocular hypertensive phase, lower intraocular pressure, and reduce medication burden.
View Article and Find Full Text PDFLoss of monocyte chemoattractant protein-1 reduced monocyte recruitment and preserved retinal ganglion cells in a mouse model of hypertensive glaucoma.
Exp Eye Res
March 2025
F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:
Monocyte chemoattractant protein-1 (MCP-1)/CCL2, a potent chemokine for myeloid cells, has been associated with disease progression in glaucoma. We examined whether genetic knockout (KO) of MCP-1 affected RGC density and function, retinal myeloid cell density, and pro-inflammatory cytokine expression in the setting of microbead induced hypertensive glaucoma. Adult wildtype (WT) C57BL/6J or MCP-1 KO mice received bilateral injections of either magnetic microbeads to elevate intraocular pressure (IOP) or balanced salt solution (BSS) as normotensive controls.
View Article and Find Full Text PDFPrenatal PFAS exposures and cardiometabolic health in middle childhood in the MIREC cohort.
Environ Res
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Department of Epidemiology, Brown University, Providence, RI, United States. Electronic address:
Studies on prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and cardiometabolic health in childhood have produced inconsistent results. In this study, we evaluated associations between prenatal PFAS exposures, individually and as a mixture, and cardiometabolic outcomes including insulin resistance, beta cell function, blood lipids, blood pressure and central adiposity during middle childhood (7-9 years of age) in a Canadian maternal-child cohort (n = 281). We also explored effect measure modification based on child sex and physical activity.
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