Background: Ocular complications of diabetes mellitus, such as dry eye and bacterial infection, are thought to be common in dogs, but their actual incidence is unknown. Therefore, we investigated the associations between glycaemia, tear production and conjunctival bacterial flora in diabetic dogs with cataracts.
Methods: The medical records of 30 diabetic dogs with cataracts were retrospectively examined to determine if there was an associations between blood glucose concentration at examination, Schirmer tear test (STT) results and positive bacterial cultures from conjunctival swabs.
Results: Eighteen dogs (60%) had low STT results, and 11 dogs (36.6%) with an STT result of 15 mm/min or less were also dysglycaemic. Positive cultures were obtained in 13 dogs (43%), 69% of which had an STT result of 15 mm/min or less and/or an inadequate control of the glycaemia; both conditions were present in 46% of these dogs. No significant association between dysglycaemia and low STT results or positive bacterial culture was detected. An increased risk of a positive bacterial culture, with a statistically significant association with the right eye, was observed in dogs with low STT results. No difference was detected in the bacterial species isolated from dogs with low or normal STT results.
Limitations: The small number of cases means that the study may have been insufficiently powered to detect significant correlations.
Conclusion: No significant association was found between glycaemia, tear production and conjunctival bacterial flora in diabetic dogs with cataracts.
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http://dx.doi.org/10.1002/vetr.4965 | DOI Listing |
Science
March 2025
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Obesity is a heritable disease, but its genetic basis is incompletely understood. Canine population history facilitates trait mapping. We performed a canine genome-wide association study for body condition score, a measure of obesity, in 241 Labrador retrievers.
View Article and Find Full Text PDFJ Vet Intern Med
March 2025
Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Background: Acute patient physiologic and laboratory evaluation (APPLE) scores have not been reported in dogs with diabetic ketoacidosis (DKA).
Hypothesis: The APPLE scores will be higher in non-survivors compared with survivors, and higher scores will predict increased mortality in dogs with DKA.
Animals: Eighty-five dogs with DKA; 58 survivors (68%) and 27 non-survivors (32%).
BMC Vet Res
March 2025
Internal Medicine Department, Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK, S7N 5B2, Canada.
Background: Although dyslipidemia is commonly reported in dogs, comparative data on the magnitude of serum cholesterol disturbances have not been reported. We aimed to describe the severity of hyper- and hypocholesterolemia in dogs with common endocrinopathies and to evaluate its association with common laboratory parameters. Medical records were reviewed over a decade (2011-2022) for dogs with hypothyroidism, diabetes mellitus (DM), hyperadrenocorticism (HAC), or hypoadrenocorticism (HA), and included signalment, common laboratory and diagnostic imaging parameters, comorbidities, and medications.
View Article and Find Full Text PDFVet Rec
February 2025
Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche-Sez. One Health, Università Degli Studi di Milano, Milan, Italy.
Background: Ocular complications of diabetes mellitus, such as dry eye and bacterial infection, are thought to be common in dogs, but their actual incidence is unknown. Therefore, we investigated the associations between glycaemia, tear production and conjunctival bacterial flora in diabetic dogs with cataracts.
Methods: The medical records of 30 diabetic dogs with cataracts were retrospectively examined to determine if there was an associations between blood glucose concentration at examination, Schirmer tear test (STT) results and positive bacterial cultures from conjunctival swabs.
Am J Physiol Endocrinol Metab
February 2025
Department of Small Animal Clinical Sciences, University of Florida, Gainesville, FL, USA.
In health, insulin-induced-hypoglycemia (IIH) activates counterregulatory hormones responses and parasympathetic (PS) and sympathoadrenal systems which leads to increased glucagon secretion. In diabetes mellitus, these responses are impaired, resulting in greater severity and delayed recovery from hypoglycemia. These counterregulatory responses in health and disease have been documented in humans, rodents, and dogs, but not yet in cats.
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