Onychopapilloma is a benign tumor of the nail bed and distal matrix, commonly presenting with longitudinal erythronychia and distal subungual hyperkeratosis. A 30-year-old Asian male presented with an asymptomatic, stable discoloration of the thumbnail, with longitudinal erythronychia, distal onycholysis, and V-shaped fissuring. Dermoscopy revealed splinter hemorrhages and focal distal subungual hyperkeratosis beneath the V-shaped notch. The lesion was unchanging over several years, and the patient opted for conservative management with periodic monitoring rather than biopsy. Based on clinical and dermoscopic features, onychopapilloma can often be distinguished from malignant conditions such as amelanotic melanoma and squamous cell carcinoma. Differential diagnoses include glomus tumor, trauma, Darier disease, and lichen planus. While biopsy is not needed for stable, asymptomatic cases, it is recommended if the lesion changes or becomes symptomatic.
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http://dx.doi.org/10.7759/cureus.78103 | DOI Listing |
Cureus
January 2025
Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Onychopapilloma is a benign tumor of the nail bed and distal matrix, commonly presenting with longitudinal erythronychia and distal subungual hyperkeratosis. A 30-year-old Asian male presented with an asymptomatic, stable discoloration of the thumbnail, with longitudinal erythronychia, distal onycholysis, and V-shaped fissuring. Dermoscopy revealed splinter hemorrhages and focal distal subungual hyperkeratosis beneath the V-shaped notch.
View Article and Find Full Text PDFSkin Appendage Disord
December 2024
Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Background: A wide variety of tumors can affect the nail unit, with some commonly mistaken as inflammatory or infectious diseases. Obtaining an optimal sample for histopathologic evaluation requires understanding of nail unit anatomy as well as the histopathology of the suspected nail tumor.
Summary: This review discusses clinical and histopathologic features of a subset of benign and malignant nail tumors, including subungual melanoma, nail unit squamous cell carcinoma in situ, nail unit squamous cell carcinoma, onychomatricoma, onychopapilloma, onychocytic matricoma, and onychocytic carcinoma.
Diagnostics (Basel)
October 2024
Dermatology Department, Saint Pierre and Brugmann University Hospitals, Université Libre de Bruxelles, 1000 Brussels, Belgium.
Skin Appendage Disord
October 2024
Skin Health Institute, Carlton, VIC, Australia.
Introduction: Subungual acantholytic dyskeratotic acanthoma is a rare benign tumor of epidermal keratinocytes characterized by acantholysis and dyskeratosis. Only 7 other cases have been published in the literature.
Case Presentation: A 29-year-old male presented with painful erythronychia and onycholysis of the left thumbnail.
J Am Acad Dermatol
September 2024
Department of Dermatology, Weill Cornell Medicine, New York, New York. Electronic address:
Longitudinal erythronychia (LE) is defined as a longitudinal red band of the nail(s) and is classified as localized (involvement of 1 nail) or polydactylous (involvement of more than 1 nail). The differential diagnosis is distinct for these classifications. The etiologies of localized longitudinal erythronychia are most frequently benign subungual neoplasms and less often malignancies.
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