AI Article Synopsis
- The study examined the effects of a lethal dose of phoschlor on dogs under Eunarkon anesthesia, focusing on proteolytic activity in blood plasma and hemolyzed blood.
- Significant metabolic disturbances in the proteolytic system were observed, with both APR-3.5 and APR-7.4 levels increasing over time.
- The increase in APR levels was not due to direct enzyme activation by the pesticide but occurred outside the bloodstream.
Article Abstract
On dogs under Eunarkon anesthesia (0,03 ml Eunarkon/kg body weight) after one intramuscular lethal injection of phoschlor (500 mg/lg body weight = LD100) the proteolytic activity (APR) was estimated in the blood plasma at pH 3,5-APR-3,5 and in the hemolyzed blood at pH-7,4-APR-7,4. The results showed that heavy poisoning with phoschlor led to metabolic disturbances in the proteolytic system of the blood plasma and blood, the expression of which was increasing in the course of time a statistically important increase (alpha = 0,001) of APR-3,5 and APR-7,4. APR induction in blood is not a result of direct activation of enzymes by pesticides. It takes place outside the circulation system.
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