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The intersection of aging and estrogen in osteoarthritis. | LitMetric
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The intersection of aging and estrogen in osteoarthritis.

Aysegul Atasoy-Zeybek Kelly K Showel Christopher V Nagelli Jennifer J Westendorf Christopher H Evans

NPJ Womens Health

Musculoskeletal Gene Therapy Research Laboratory, Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN USA.

Published: February 2025

Osteoarthritis (OA) is a chronic joint disease characterized by cartilage degradation, inflammation, and pain. While multiple factors contribute to OA development, age and sex are primary risk factors, particularly affecting postmenopausal women. The dramatic increase in OA risk after menopause suggests estrogen deficiency accelerates disease progression. This review explores the molecular mechanisms connecting aging and estrogen deficiency in OA development, focusing on key genes and pathways identified through RNA sequencing.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11860234PMC
http://dx.doi.org/10.1038/s44294-025-00063-1DOI Listing

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