Background: Nearly 7,000 snakebite injuries are reported yearly in the United States, with almost one quarter of those in the pediatric population. Due to increased exposure to snakes, rural children may experience different clinical outcomes for snakebite injuries. The goal of this study was to examine differences in resource utilization of rural and urban pediatric patients with snakebite injuries.
Methods: This is a retrospective cross-sectional study of patients aged 21 years and under presenting with venomous snakebites in the United States from January 1, 2016, through March 31, 2023, using the Pediatric Hospital Information System database and ICD-10 codes indicating snakebites. Comparisons were conducted to evaluate demographic and clinical characteristics in association with resource utilization and complications between patients living in rural areas and patients living in urban areas.
Results: The study included 2,633 patients from 23 states. The median age was 9 years; 61% of patients were male. Most patients were in the South and over 70% resided in urban areas. 82% of the population was admitted to a hospital, with median length of stay 1.59 days. Compared to urban patients, rural patients were more likely to be admitted and receive antivenom but were less likely to have an intensive care unit admission and have abnormal coagulation studies.
Conclusions: Rural pediatric patients with snakebites had different resource utilization and clinical complications than urban patients.
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http://dx.doi.org/10.1186/s40621-025-00563-3 | DOI Listing |
G3 (Bethesda)
March 2025
Institute of Forest Sciences (ICIFOR-INIA), Consejo Superior de Investigaciones Cientificas, 28040 Madrid, Spain.
Stone pine (Pinus pinea L.) is an emblematic tree species within the Mediterranean basin, with high ecological and economic relevance due to the production of edible nuts. Breeding programmes to improve pine nut production started decades ago in Southern Europe but have been hindered by the near absence of polymorphisms in the species genome and the lack of suitable genomic tools.
View Article and Find Full Text PDFAm J Public Health
April 2025
Kristen M. Brown, Brigette Courtot, Zara Porter, and Sofia Hinojosa are with the Health Policy Center, Urban Institute, Washington, DC.
The Centers for Disease Control and Prevention's Partnering for Vaccine Equity program was developed during the COVID-19 public health emergency to fund more than 500 community-based organizations working to improve vaccine equity. Organizations were supported by a virtual learning community where members received tailored learning content, peer-to-peer learning opportunities, and resources that facilitated deployment of vaccine-related programming during a dynamic pandemic. Process evaluation metrics indicate successful implementation of the learning community.
View Article and Find Full Text PDFJ Med Chem
March 2025
State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine; Shanghai Frontiers Science Center of TCM Chemical Biology; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
The anticancer agent irinotecan often induces severe delayed-onset diarrhea, inhibiting human carboxylesterase 2A (hCES2A) can significantly alleviate irinotecan-triggered gut toxicity (ITGT). This work presents an efficient workflow for design and developing novel efficacious hCES2A inhibitors. A well-training machine learning model identified as a lead compound, while compound was developed as a novel time-dependent hCES2A inhibitor (IC = 0.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
March 2025
University of Oulu: Oulun Yliopisto, NMR Research Unit, FINLAND.
Reduction of the germole-ligated sandwich complexes [(η5-CpGe)M(η5-Cpttt)]2 (1M, M = Y, Gd, Dy) with one or two equivalents of KC8/2.2.2-cryptand produces [(η5-CpGe)M(η5-Cpttt)2]- (2M) and [(η5-CpGe)M(η5-Cpttt)2]2- (3M), respectively, as salts of [K(2.
View Article and Find Full Text PDFHealth Promot Chronic Dis Prev Can
March 2025
Evidence Synthesis and Knowledge Translation Unit, Centre for Surveillance and Applied Research, Health Promotion and Chronic Disease Prevention Branch, Public Health Agency of Canada, Ottawa, Ontario, Canada.
Introduction: We investigated the prevalence of new or persistent manifestations experienced by COVID-19 survivors at 3 or more months after their initial infection, collectively known as post-COVID-19 condition (PCC).
Methods: We searched four electronic databases and major grey literature resources for prospective studies, systematic reviews, authoritative reports and population surveys. A random-effects meta-analysis pooled the prevalence data of 22 symptoms and outcomes.
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