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Oral colon-targeted responsive chitosan/pectin-based nanoparticles propels the application of tofacitinib in colitis therapy.
Sci Rep
January 2025
School of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao, China.
Tofacitinib (Tof), a commercially available pan-Janus kinases inhibitor, is approved for the treatment of moderate to severe ulcerative colitis. However, its clinical application is limited due to dose-dependent systemic side effects. The present study aims to develop an efficient oral colon-targeted drug delivery systems using prebiotic pectin (Pcn) and chitosan (Csn) polysaccharides as a shell, with Tof loaded into a Bovine Serum Albumin (BSA) core, and improving it with chondroitin sulfate (Chs), thus constructing Tof@BSA-Chs-CP nanoparticles (NPs).
View Article and Find Full Text PDFA comparison of the clinicopathological features and genetic alterations in stage II/III gastric cancer with no recurrence, early recurrence and late recurrence after curative surgery.
J Chin Med Assoc
November 2024
School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.
Background: Few studies have explored the genetic changes and clinicopathological features of stage II/III gastric cancer (GC) patients with no tumor recurrence, early recurrence, or late recurrence after curative surgery.
Methods: In this study, 376 patients who underwent curative surgery for stage II/III GC were analyzed. The clinical and genetic features of patients with no recurrence, early recurrence (<2 years), and late recurrence (≥2 years) were compared.
Mechanistic insight into human milk extracellular vesicle-intestinal barrier interactions.
J Extracell Biol
January 2025
Human milk extracellular vesicles (EVs) are crucial mother-to-baby messengers that transfer biological signals. These EVs are reported to survive digestion and transport across the intestine. The mechanisms of interaction between human milk EVs and the intestinal mucosa, including epithelial uptake remain unclear.
View Article and Find Full Text PDFAntimicrobial Potentials of Haliclona fibulata Derived Compounds for Combatting Drug-Resistant Bacterial Infections in Zebrafish Model.
Chem Biodivers
January 2025
SRM Institute of Science and Technology: SRM Institute of Science and Technology (Deemed to be University), Department of Chemical Engineering, Kattankulathur, 603203, Chengalpattu, INDIA.
The rising threat of antimicrobial resistance among pathogens highlights the critical need for novel antimicrobial agents. This study explores the potential of natural products by investigating hexane extracts from the marine sponge Haliclona fibulata (HF) for their antibacterial efficacy. The well diffusion method of HF extract showed significant antibacterial activity against P.
View Article and Find Full Text PDFThe unseen spread-Schnitzler's metastasis unveiled: a case report.
Korean J Clin Oncol
December 2024
Institute of Surgical Gastroenterology and Liver transplantation, Government Stanley Medical College, Chennai, India.
Metastasis to the rectum is very rare and is usually caused by primaries from the breast, gastrointestinal tract, and genitourinary system. We report here a case of acute intestinal obstruction caused by an unusual rectal stenosis, for which he underwent a diversion stoma. On extensive evaluation for the etiology of the rectal stenosis, he was diagnosed with diffuse gastric cancer with Schnitzler's metastasis to the rectal submucosa.
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