The red flour beetle, Tribolium castaneum (Herbst) is a cosmopolitan insect pest that causes severe loss in broad range of stored commodities worldwide. Chemical control has been considered as major preventive measure to manage this dangerous pest. Therefore, we have evaluated 22 different insecticides against T. castaneum collected from five districts of southern Punjab, Pakistan. Bioassays were performed to assess the LC values of considered insecticides. Our results showed that emamectin benzoate was the most toxic insecticide among all the insecticides. There was non-significant difference in toxicity of deltamethrin and triazophos to all tested populations based on overlapping 95% confidence interval of LC. The spinosad was more toxic as compared with the spinetoram. In case of ketoenoles, spirotetramat was more toxic as compared with the spiromesifen. In case of acetamaprid and nitenpyram, there is non- significant difference in LC values of the all tested strains of T. castaneum based on overlapping 95%CI. We used four insect growth regulators (IGRS) including methoxyfenozide, pyriproxyfen, lufenuron and cyromazine as larvicides. The lufenuron was more toxic as compared with the pyriproxyfen, methoxyfenozide and cyromazine in most of the studied populations. Methoxyfenozide was moderately toxic. These results will provide help in establishing an effective management program for T. castaneum.
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http://dx.doi.org/10.1038/s41598-025-88915-3 | DOI Listing |
Mol Pharm
March 2025
Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Positive surgical margins following radical prostatectomy significantly contribute to tumor recurrence. While systemic chemotherapy demonstrates limited efficacy in this context, local chemotherapy drug delivery systems based on nanomaterials offer promising strategies to address this issue by modifying drug release kinetics and distribution, thereby enhancing antitumor effects while minimizing the toxicities associated with systemic chemotherapy. In this study, we utilized electrospun nanofibrous mats loaded with docetaxel for sustained drug delivery.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
March 2025
Laboratorio 1. Centro de Investigación del Cáncer, Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas-Universidad de Salamanca and Centro de Investigación Biomédica en Red Cáncer (CIBERONC), Salamanca 37007, Spain.
We evaluated the in vivo therapeutic efficacy and tolerability of BI-3406-mediated pharmacological inhibition of SOS1 in comparison to genetic ablation of this universal Ras-GEF in various KRAS-dependent experimental tumor settings. Contrary to the rapid lethality caused by SOS1 genetic ablation in SOS2 mice, SOS1 pharmacological inhibition by its specific inhibitor BI-3406 did not significantly affect animal weight/viability nor cause noteworthy systemic toxicity. Allograft assays using different KRAS cell lines showed that treatment with BI-3406 impaired RAS activation and RAS downstream signaling and decreased tumor burden and disease progression as a result of both tumor-intrinsic and -extrinsic therapeutic effects of the drug.
View Article and Find Full Text PDFEnviron Geochem Health
March 2025
Institute of Soil Fertilizer and Agricultural Water Saving, Xinjiang Academy of Agricultural Sciences, Urumqi, 830091, People's Republic of China.
Microplastics (MPs), as a global environmental issue, have unclear impacts on agricultural ecosystems. Cotton, as a major agricultural crop in Xinjiang, requires plastic film covering to ensure its yield. The widespread use of plastic film (commonly made of polyethylene) in cotton cultivation has led to significant concerns about microplastic pollution in cotton fields.
View Article and Find Full Text PDFJ Biomater Appl
March 2025
Department of Chemistry, School of Pharmacy, North Sichuan Medical College, Nanchong, China.
Colorectal cancer is the fourth leading cause of cancer-related deaths worldwide. Capecitabine is a chemotherapeutic agent commonly used for the treatment of colon cancer. To realize local sustained release, promote efficient local intracellular transport, and mitigate the systemic toxic effects of capecitabine, a capecitabine prodrug, capecitabine-poly (p-dioxanone) (Cap-PPDO), was successfully synthesized.
View Article and Find Full Text PDFPlant Biol (Stuttg)
March 2025
School of Biological Sciences, Monash University, Melbourne, Victoria, Australia.
Moderately saline water has been proposed as a potential irrigation resource for crops such as forage sorghum (Sorghum bicolor × Sorghum bicolor nothosubsp. drummondii) in drought-prone regions. However, it is not yet fully understood how salinity affects growth and potential toxicity of sorghum.
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