Background: While there is substantial evidence on the impact of prehospital resuscitation efforts on survival after out-of-hospital cardiac arrest (OHCA), the importance of the first electrocardiogram after return of spontaneous circulation has been much less studied.
Objectives: The aim of this study was to identify prognostically relevant electrocardiographic findings in patients after OHCA due to myocardial infarction (MI).
Methods: A total of 119 patients admitted to hospital after suffering an OHCA due to MI were retrospectively analyzed. Patient characteristics and the first 12-lead electrocardiogram after return of spontaneous circulation were collected. The primary outcome was 30-day mortality.
Results: A number of electrocardiographic findings were significantly associated with 30-day mortality: atrial fibrillation/flutter (HR 2.29 [95% CI 1.17-4.49, p = 0.015]), right bundle branch block (HR 2.23 [95% CI 1.14-4.56, p = 0.020]), bifascicular block (HR 2.51 [95% CI 1.04-6.059, p = 0.040]), T inversion (HR 2.01 [95% CI 1.02-3.99, p = 0.043]), QTc duration ≥500 ms (HR 2.21 [95% CI 1.10-4.42, p = 0.025]) and QT dispersion ≥ 100 ms (HR 2.11 [95% CI 1.02-4.37, p = 0.045]).
Conclusion: Several different electrocardiographic findings are associated with increased mortality in patients with OHCA due to MI.
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http://dx.doi.org/10.1016/j.jemermed.2024.09.010 | DOI Listing |
Circ J
March 2025
Department of Cardiovascular Medicine, Shinshu University School of Medicine.
Background: The EMPA-REG OUTCOME trial confirmed empagliflozin reduced mortality and heart failure hospitalization risk. These findings raised the possibility that empagliflozin may modulate cardiac autonomic function in patients with type 2 diabetes (T2D).
Methods And Results: The EMPYREAN study was a prospective randomized open-label assessor-blinded multicenter investigation of patients with T2D without prior antidiabetic therapy with sodium-glucose cotransporter 2 or dipeptidyl peptidase 4 inhibitors.
BMJ Open
March 2025
Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China
Introduction: Primary headaches pose a significant burden on children and adolescents, highlighting the need for effective non-pharmacological interventions. Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive modality that has demonstrated efficacy in adult populations with primary headaches and has shown safety in adolescents with mental health disorders. However, its effectiveness in managing acute headache episodes and preventing recurrences in paediatric populations remains underexplored.
View Article and Find Full Text PDFGeroscience
March 2025
Department of Medicine, College of Human Medicine, Michigan State University, 1355 Bogue St, East Lansing, MI, 48824, USA.
Transient receptor potential ankyrin 1 (TRPA1) is a sensory channel expressed in vagal afferent nerves that detect noxious stimuli. Trpa1 knockout accelerates age-related cardiac fibrosis and dysfunction in mice. This study investigated whether TRPA1 activation with its selective agonist, allyl isothiocyanate (AITC), prevents cardiac aging.
View Article and Find Full Text PDFAnn Noninvasive Electrocardiol
March 2025
Department of Cardiology, Tokat Gaziosmanpasa University Hospital, Tokat, Turkey.
Introduction: Various ventricular repolarization parameters are known to predict ventricular arrhythmias and mortality in various diseases. Although mortality in patients with heart failure with preserved ejection fraction (HFpEF) is similar to that in heart failure with reduced ejection fraction patients, studies on this subject are more limited. Therefore, it is important to evaluate the relationship between ventricular arrhythmias and mortality and ventricular repolarization parameters, especially the frontal plane QRS-T angle, in patients with HFpEF.
View Article and Find Full Text PDFJ Opioid Manag
March 2025
Department of Clinical Pharmacy Research and Education, Osaka University Graduate School of Pharmaceutical Sciences, Suita, Osaka, Japan.
Objective: Methadone may cause detrimental side effects such as corrected QT (QTc) prolongation. However, methadone may be desirable in patients with advanced cancer and those with heart disease who have intractable pain. Therefore, we aimed to evaluate the safety and efficacy of initiating methadone for cancer pain in patients at high risk of methadone-induced QTc prolongation.
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