The management of perianal Crohn's disease is challenging and complex and requires a multidisciplinary approach as a favorable working relationship between gastroenterologists and colorectal surgeons is necessary to provide excellent care for this patient population. The use of biologic therapy has impacted the treatment of this disease process, but surgical options have failed to reach the success rates seen in cryptoglandular and traumatic pathologies of the anus. The general management of perianal disease involves control of sepsis, control of anorectal symptoms, minimizing resultant complications and avoidance of proctectomy when possible.
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http://dx.doi.org/10.1016/j.suc.2024.09.007 | DOI Listing |
Int J Colorectal Dis
March 2025
Department of General Surgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Purpose: There is no consensus on the standard approach for trans-sphincteric perianal fistulas (TPAF) in the elderly population. The most commonly used sphincter-saving procedures are ligation of the inter-sphincteric fistula tract (LIFT) and mucosal advancement flap (MAF). We aimed to evaluate the incidence and risk factors for recurrence and incontinence in elderly patients with TPAF using both approaches.
View Article and Find Full Text PDFWorld J Gastroenterol
March 2025
Department of Anatomy, Division of Human Biology, School of Medicine, IMU University, Kuala Lumpur 57000, Malaysia.
Perianal fistulizing Crohn's disease (PFCD) is a common presentation of CD, which affects the patients' quality of life, including social and sexual function. The management of PFCD remains a critical challenge in inflammatory bowel disease, primarily due to limited understanding of the mechanisms involved in its pathogenesis, complicating medical treatment. Increased production of inflammatory cytokines such as tumor necrosis factor and interleukin-13 by infiltrating macrophages and other inflammatory cells stimulate the epithelial-to-mesenchymal transition, resulting in activation of myofibroblasts and elevation of matrix metalloproteinases, leading to fistula formation.
View Article and Find Full Text PDFAnn Med
December 2025
Department of Anesthesiology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Objective: This study aims to evaluate the effectiveness of transcutaneous auricular vagus nerve stimulation (taVNS) on postoperative pain in patients following perianal surgery.
Methods: 96 patients were randomly assigned to either the taVNS group or the sham stimulation group. Patients received stimulation once 30 min before the operation and once more 24 h after the operation, with each session lasting 30 min.
Surg Clin North Am
April 2025
Department of Surgery, Univeristy of Oklahoma Health Sciences, 800 SL Young Boulevard Suite 9000, Oklahoma City, OK 73104, USA. Electronic address:
The management of perianal Crohn's disease is challenging and complex and requires a multidisciplinary approach as a favorable working relationship between gastroenterologists and colorectal surgeons is necessary to provide excellent care for this patient population. The use of biologic therapy has impacted the treatment of this disease process, but surgical options have failed to reach the success rates seen in cryptoglandular and traumatic pathologies of the anus. The general management of perianal disease involves control of sepsis, control of anorectal symptoms, minimizing resultant complications and avoidance of proctectomy when possible.
View Article and Find Full Text PDFEur Spine J
February 2025
National Spinal Injuries Unit, Mater Misericordiae University Hospital, Dublin, Ireland.
Background Context: Cauda Equina Syndrome (CES) is an emergency clinical syndrome with correlating radiological evidence of spinal compression. Urgent recognition and treatment is key. In many units, it lacks a clear pathway of investigation and referral, despite a constantly expanding evidence base for its management.
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