Peritoneal surface malignancies (PSM) includes an expansive disease spectrum, ranging from low-grade appendiceal mucinous neoplasm to metastatic processes from invasive adenocarcinomas of the gastrointestinal tract. Management of PSM faces numerous challenges, from diagnosis to delivery of care, both from a treatment and navigational standpoint. This article outlines the various hurdles faced at different branch points and current management recommendations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.soc.2024.11.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Absence of c-Maf and IL-10 enables type I IFN enhancement of innate responses to LPS in alveolar macrophages.
J Immunol
March 2025
Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA, United States.
Alveolar macrophages (AMs) are lung-resident myeloid cells and airway sentinels for inhaled pathogens and environmental particles. While AMs can be highly inflammatory in response to respiratory viruses, they do not mount proinflammatory responses to all airborne pathogens. For example, we previously showed that AMs fail to mount a robust proinflammatory response to Mycobacterium tuberculosis.
View Article and Find Full Text PDFUnlabelled: Phagosome degradation is an evolutionally conserved and highly effective innate immune response against pathogen infections. The success of this process relies on the ability of phagocytes to regulate the maturation of phagosomes. However, the underlying molecular mechanisms and its roles in shaping downstream immune activation remain poorly understood.
View Article and Find Full Text PDFA Dual-Layer Hydrogel Barrier Integrating Bio-Adhesive and Anti-Adhesive Properties Prevents Postoperative Abdominal Adhesions.
Adv Healthc Mater
March 2025
Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Postoperative abdominal adhesions are a common and painful complication after surgery, leading to high healthcare costs and diminished quality of life. This report presents a novel bilayer hydrogel barrier featuring an inner adhesive layer and an outer antiadhesive layer. The inner adhesive layer hydrogel (PT) is prepared by mixing polyethyleneimine (PEI) and thioctic acid (TA).
View Article and Find Full Text PDFSuccessful pregnancy following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in patients with peritoneal malignancies.
Eur J Surg Oncol
February 2025
Department of General Surgery, The Chaim Sheba Medical Center, Ramat Gan, Israel; Department of Surgery, Ziv Medical Center, Affiliated with Bar-Ilan University School of Medicine, Tzfat, Israel.
Background: Cytoreductive surgery (CRS) with Hyperthermic Intra-peritoneal Chemotherapy (HIPEC) has become a successful, potentially curative, treatment option for peritoneal surface malignancies (PSM). CRS and HIPEC (CRS/HIPEC) are performed with curative intent for several intra-peritoneal pathologies. An increasing number of patients with PSM are diagnosed at a relatively young age.
View Article and Find Full Text PDFNIR-II AIEgen nanocomplex with suppressed nonradiative decay and intersystem crossing for high-contrast mesenteric vascular imaging.
Biomaterials
August 2025
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710048, China.
The prompt assessment of the mesenteric vasculature is crucial for the diagnosis of lethal mesenteric ischemia, underscoring the need for real-time mesenteric vascular imaging using small organic molecules that radiate fluorescence within the second near-infrared spectrum (NIR-II) due to its deep penetration and elevated signal-to-background ratio (SBR), which have been rarely reported. Unfortunately, numerous NIR-II dyes exhibit low quantum yields (QYs) when employed in practical applications, highlighting the need for QY enhancement. For this research, a NIR-II fluorescent AIEgen, termed TPETPA-TQT, was rationally designed by incorporating tetraphenylethylene (TPE)-fused triphenylamine (TPA) into the robust, high QY core of 6,7-di(thiophen-2-yl)-[1,2,5]thiadiazolo[3,4-g]quinoxaline (TQT).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!