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Revealing a Heavy-Atom Assisted Rotation Mechanism in the H + NHCl Multi-Channel Reaction.
J Phys Chem A
March 2025
State Key Laboratory of Magnetic Resonance Spectroscopy and Imaging, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, China.
Identifying atomic-level mechanisms in elemental chemical reactions is crucial for understanding complex reaction processes. This study focuses on the typical multichannel H + NHCl reaction, which plays a significant role in environmental science. High-level ab initio calculations determined seven distinct reaction pathways, leading to three product channels: H + NHCl, HCl + NH, and Cl + NH.
View Article and Find Full Text PDFCAR assembly line: Taking CAR T-cell manufacturing to the next level.
Best Pract Res Clin Haematol
December 2024
Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
The widespread adoption of chimeric antigen receptor (CAR) T-cell therapy has been limited by complex, resource-intensive manufacturing processes. This review discusses the latest innovations aiming to improve and streamline CAR T-cell production across key steps like T-cell activation, genetic modification, expansion, and scaling. Promising techniques highlighted include generating CAR T cells from non-activated lymphocytes to retain a stem-like phenotype and function, non-viral gene transfer leveraging platforms like transposon and CRISPR, all-in-one fully automated bioreactors like the CliniMACS Prodigy and the Lonza Cocoon, rapid CAR T-cell manufacturing via abbreviating or eliminating ex vivo T-cell culture, implementing decentralized point-of-care automated manufacturing platforms, and optimizing centralized bioreactor infrastructure integrating end-to-end automation.
View Article and Find Full Text PDFTelomeric RNA quadruplexes as targets for cancer prevention: The therapeutic potential of agonodepsides.
J Genet Eng Biotechnol
March 2025
Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India. Electronic address:
Background: Cancer remains an awful challenge, despite years of targeting proteins to control its relentless growth and spread. Fungal metabolites, a treasure of natural chemicals, offer a glimmer of hope. Telomeres, the cellular "caps," are a focal point in cancer research.
View Article and Find Full Text PDFHemispheric asymmetries, paleoneurology, and the evolution of the human genus.
Handb Clin Neurol
March 2025
Departamento de Paleobiología, Museo Nacional de Ciencias Naturales, CSIC, Madrid, Spain; Reina Sofia Alzheimer Center, CIEN Foundation, ISCIII, Madrid, Spain. Electronic address:
Brain asymmetries are a distinctive feature of Homo sapiens and are associated with key evolutionary functions including language and handedness. Nonetheless, differences between humans and apes could be just a matter of degree and size and not the expression of unique traits of our species. In this chapter, I introduce paleoneurology and the study of brain morphology in fossil hominids, reviewing the anatomic factors that can influence the main asymmetries of the endocranial cavity (cortical volumes, sulcal patterns, and craniovascular features).
View Article and Find Full Text PDFAssociation Between Cardiovascular Biological Age and Cardiovascular Disease - A Prospective Cohort Study.
Circ J
March 2025
West China School of Public Health and West China Fourth Hospital, Sichuan University.
Background: Biological age serves as a common starting point for various age-related diseases and can be associated with a wide range of cardiovascular outcomes. However, associations between cardiovascular biological age (CBA) and various types of cardiovascular disease (CVD) remain unclear.
Methods And Results: Analyzing 262,343 UK Biobank participants, we constructed CBA based on composite biomarkers using the Klemera-Doubal method (denoted as KDM-CBA).
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