Background: The quality of life of pediatric patients born with gastroschisis has yet to be documented in a systematic review. Our objective is to quantitatively summarize the parent and child-reported quality of life outcomes of children born with gastroschisis.
Methods: Records were sourced from the MEDLINE, PsycInfo, EBM Reviews, and Embase databases. Studies that examined child and parent-reported quality of life outcomes in pediatric patients with gastroschisis were included. Screening and data extraction was conducted by three reviewers. The primary outcome was the reported quality of life functioning scores, and the secondary outcomes included gastrointestinal symptoms and nutritional limitations. A random effects meta-analysis and sensitivity analysis were performed.
Results: 2695 articles were screened, and eight studies were included. Pooled parent-reported quality of life mean estimate scores were higher in the realms of physical and emotional functioning, with lower psychosocial and school functioning scores. Child-reported pooled standardized mean scores showed higher perceived physical functioning and social functioning with lower emotional and school functioning scores. Pooled parent-reported gastrointestinal symptom mean estimate scores showed higher heartburn and reflux, difficulty swallowing, nausea and vomiting, diarrhea, and food and drink limitation scores, representing improved clinical outcomes in those domains. Lower scores were noted in the domains of abdominal pain and constipation, indicating worse clinical outcomes in these domains.
Conclusion: The pediatric gastroschisis population has better quality of life scores in physical functioning with poorer abdominal pain and constipation scores. These symptoms should be highlighted when counselling the parents of these patients.
Level Of Evidence: V.
Type Of Study: Reviews, Systematic Reviews, Meta-Analyses, and Guidelines.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jpedsurg.2025.162222 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Perioperative Trends in Distress Among Cancer Patients: A Systematic Review and Meta-Analysis.
Cancer Med
March 2025
Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina, USA.
Introduction: Distress is common among cancer patients, especially those undergoing surgery. However, no study has systematically analyzed distress trends in this population. The purpose of this study was to systematically review perioperative rates of distress, as well as differences across cancer types, in cancer patients undergoing surgical intervention.
View Article and Find Full Text PDFUnderstanding Personalized Dynamics in Eating Disorders: A Dynamic Time Warp Analysis.
Int J Eat Disord
March 2025
Rivierduinen Eating Disorders Ursula, Leiden, the Netherlands.
Objective: To enhance our understanding of the processes of change and the interaction of symptoms, we applied a relatively novel method known as Dynamic Time Warp to data from low-threshold internet-based interventions directed at decreasing eating disorder (ED) symptoms and increasing help-seeking.
Method: Utilizing data from the Featback study, we examined how various factors such as ED psychopathology, binge eating, vomiting, laxative use, BMI, anxiety, depression, self-efficacy, social support, well-being, and health-related quality of life interplayed over a period of 14 months among 355 individuals at six different time points. Moreover, we explored which symptoms exerted a significant temporal relationship on others (with high out-strength) and which were most affected by other symptoms (with high in-strength).
Evaluation of Nutritional Values of Defatted Black Soldier Fly (Hermetia illucens) Larvae Meal Using the Precision-Fed Cecectomized Rooster Assay.
J Anim Sci
March 2025
Department of Animal Sciences, University of Illinois, Urbana, IL 61801.
The use of insects, such as black soldier fly (Hermetia illucens) larvae meal (BSFLM), as an alternative protein source for pet food has gained attention due to their high nutritional value. The objective of this study was to determine the chemical composition, amino acid digestibility, and protein quality of defatted BSFLM of two distinct substrates (wheat and corn, BSFLM-W and BSFLM-C). Whole egg powder (WEP) and chicken meal (CM) were used as reference protein sources commonly used in pet foods.
View Article and Find Full Text PDFAmino Acid Digestibility of Yellow Mealworm-Based Ingredients using the Precision-Fed Cecectomized Rooster Assay.
J Anim Sci
March 2025
Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Yellow mealworms (Tenebrio molitor) serve as an alternative protein source. Because the amino acid (AA) concentrations, AA digestibility, and protein quality of ingredients may vary depending on their husbandry, harvest and processing procedures, and other factors, each should be evaluated separately. The objective of this study was to measure the AA composition, AA digestibility, and protein quality of yellow mealworm-based ingredients using the precision-fed cecectomized rooster assay.
View Article and Find Full Text PDFHemophilia is associated with accelerated biological aging.
Haematologica
March 2025
Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of Vienna; Vienna.
Hemophilia is a rare X-linked bleeding disorder caused by mutations in the F8 or F9 gene (hemophilia A or B), leading to deficient factor VIII or IX proteins, respectively. Hemophilia-related complications caused by bleeding into the joints (the hallmark of hemophilia) and age-related comorbidities occur frequently and impact the functionality and quality of life of persons with hemophilia (PwH). Given the chronic nature of hemophilia, we hypothesized that hemophilia has an association with accelerated biological aging.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!